Wood Casey, Almes Kelli, Bagladi-Swanson Mary, Debey Brad, Andrews Gordon, Nietfeld Jerome, Wilkerson Melinda
Department of Diagnostic Medicine, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, Kansas 66506-5705, USA.
J Am Anim Hosp Assoc. 2008 May-Jun;44(3):144-8. doi: 10.5326/0440144.
Sézary syndrome is an uncommon leukemic variant of cutaneous lymphoma in cats. This cat had recurrent dermatitis with erythematous, pruritic plaques. Multiple skin imprints and biopsy samples were obtained over a 6-month period, and histopathological findings were consistent initially with eosinophilic miliary dermatitis and later with erythema multiforme. One week before death, Sézary cells were identified in the peripheral blood that expressed cluster of differentiation (CD)3 and CD8 antigens. Massive infiltration of CD3+ lymphocytes was noted in the skin and multiple internal tissues by histopathological examination. This case demonstrates the difficulty in diagnosing cutaneous lymphoma early in the disease course.
蕈样肉芽肿综合征是猫皮肤淋巴瘤中一种罕见的白血病变体。这只猫患有复发性皮炎，伴有红斑、瘙痒性斑块。在6个月的时间里获取了多个皮肤压印片和活检样本，组织病理学检查结果最初与嗜酸性粟粒性皮炎一致，后来与多形红斑一致。在死亡前一周，在外周血中发现了表达分化簇（CD）3和CD8抗原的蕈样肉芽肿细胞。组织病理学检查发现皮肤和多个内部组织中有大量CD3 +淋巴细胞浸润。该病例表明在疾病病程早期诊断皮肤淋巴瘤存在困难。
