Yoshikawa Masayuki, Nakamura Seikou, Li Xuezheng, Matsuda Hisashi
Kyoto Pharmaceutical University, Kyoto, Japan.
Chem Pharm Bull (Tokyo). 2008 May;56(5):695-700. doi: 10.1248/cpb.56.695.
Three new (-)-rosiridol glycosides, rosiridosides A, B, and C, were isolated from the roots of Rhodiola sachalinensis together with rosiridin [(-)-rosiridol 1-O-beta-D-glucopyranoside]. In the course of the structure elucidation of those new glycosides, the absolute configuration of the 4-position in (-)-rosiridol was reinvestigated. On the basis of the application of the modified Mosher's method for (-)- and (+)-rosiridol derivatives, the absolute configuration of the 4-position in (-)-rosiridol should be revised to be S orientation from the recently assigned R form, so that the absolute stereostructures of rosiridosides A, B, and C and rosiridin were determined.
从库页红景天的根部分离出三种新的（-）-罗西瑞醇糖苷，即罗西瑞糖苷A、B和C，以及罗西瑞定[（-）-罗西瑞醇1-O-β-D-吡喃葡萄糖苷]。在对这些新糖苷进行结构解析的过程中，对（-）-罗西瑞醇中4位的绝对构型进行了重新研究。基于对（-）-和（+）-罗西瑞醇衍生物应用改进的莫舍尔方法，（-）-罗西瑞醇中4位的绝对构型应从最近指定的R构型修正为S构型，从而确定了罗西瑞糖苷A、B和C以及罗西瑞定的绝对立体结构。
