Weitzel William F
University of Michigan, Department of Internal Medicine, Division of Nephrology, 102 Observatory, 312 Simpson Memorial Institute, Ann Arbor, Mich., USA.
Contrib Nephrol. 2008;161:23-29. doi: 10.1159/000129750.
There is increasing emphasis on optimizing fistula use for end-stage renal disease patients. Although early referral and strategies for vein preservation are clearly important, imaging modalities have assumed an ever-increasing role in preoperative vascular access assessment and management.
METHODS/RESULTS: Review of available literature demonstrates angiography and ultrasonography provide anatomic information useful in diagnostic decision-making in many clinical settings. Targeted clinical programs can increase fistula use, and various practice patterns have emerged to achieve this goal depending on the available expertise, center-dependent experience, and differing patient populations. In recent years there have been a series of studies evaluating provocative maneuvers assessing vascular mechanics that attempt to increase the predictive power of imaging modalities. Assessing arterial and venous mechanics may help predict outcomes and assist in preoperative planning.
In the quest to optimize fistula use, study results examining the value of angiography and ultrasonography demonstrate that there is currently no universal application of specific cut-offs on vessel diameter or even measures of distensibility and vessel mechanics. It is clear, however, that implementing programs that include imaging to increase fistula creation do achieve their goal. Conversely, in other settings, fistula failure rates have increased without significantly increasing the numbers of fistulae. The impact of preoperative diagnostic angiography and ultrasonography rests in part on identifying the underlying disease process involving arteries and veins that may change treatment decisions preoperatively. In many clinical settings where the dialysis population is becoming increasingly elderly, diabetic and with more vascular disease, these additional studies may be very useful. Given the variation in clinical study outcome and variations in patient populations, presently these methods will be used most effectively in the setting of strong quality assurance programs, and wherever feasible under study protocols for the purpose of improving practice patterns.
终末期肾病患者瘘管使用的优化日益受到重视。尽管早期转诊和静脉保护策略显然很重要,但成像方式在术前血管通路评估和管理中发挥着越来越重要的作用。
方法/结果:对现有文献的回顾表明,血管造影和超声检查可提供解剖学信息,在许多临床环境的诊断决策中很有用。有针对性的临床项目可以增加瘘管的使用,并且根据可用的专业知识、中心相关经验和不同的患者群体,已经出现了各种实践模式来实现这一目标。近年来,有一系列研究评估了评估血管力学的激发性操作,试图提高成像方式的预测能力。评估动脉和静脉力学可能有助于预测结果并协助术前规划。
在优化瘘管使用的探索中,研究造影和超声检查价值的结果表明,目前对于血管直径的特定临界值甚至扩张性和血管力学测量,并没有普遍适用的标准。然而,很明显,实施包括成像在内的项目以增加瘘管的创建确实实现了目标。相反,在其他情况下,瘘管失败率增加,而瘘管数量没有显著增加。术前诊断性血管造影和超声检查的影响部分在于识别涉及动脉和静脉的潜在疾病过程,这可能会改变术前的治疗决策。在许多透析人群日益老龄化、患有糖尿病且血管疾病更多的临床环境中,这些额外的研究可能非常有用。鉴于临床研究结果的差异和患者群体的差异,目前这些方法将在强大的质量保证项目环境中最有效地使用,并且在可行的情况下,根据研究方案用于改善实践模式。