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本文引用的文献

1
Interaction of nicotine with dopaminergic mechanisms assessed through drug discrimination and rotational behaviour in rats.通过大鼠的药物辨别和旋转行为评估尼古丁与多巴胺能机制的相互作用。
J Psychopharmacol. 1987 Jan;1(4):264-73. doi: 10.1177/026988118700100408.
2
Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism.长期接触尼古丁通过一种新机制上调烟碱型受体。
J Neurosci. 2005 Jun 8;25(23):5563-72. doi: 10.1523/JNEUROSCI.5240-04.2005.
3
The neurobiology of tobacco dependence: a preclinical perspective on the role of the dopamine projections to the nucleus accumbens [corrected].烟草依赖的神经生物学：关于多巴胺投射至伏隔核作用的临床前视角[已修正]
Nicotine Tob Res. 2004 Dec;6(6):899-912. doi: 10.1080/14622200412331324965.
4
Nicotine-induced dopamine release in the nucleus accumbens is inhibited by the novel AMPA antagonist ZK200775 and the NMDA antagonist CGP39551.新型AMPA拮抗剂ZK200775和NMDA拮抗剂CGP39551可抑制尼古丁诱导的伏隔核多巴胺释放。
Psychopharmacology (Berl). 2004 Aug;175(1):114-23. doi: 10.1007/s00213-004-1797-7. Epub 2004 Apr 16.
5
The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour.尼古丁成瘾的神经生物学：弥合从分子到行为的差距。
Nat Rev Neurosci. 2004 Jan;5(1):55-65. doi: 10.1038/nrn1298.
6
The neurobiology of opiate tolerance, dependence and sensitization: mechanisms of NMDA receptor-dependent synaptic plasticity.阿片类药物耐受性、依赖性和敏化的神经生物学：NMDA受体依赖性突触可塑性机制
Neurotox Res. 2002 Jun;4(4):373-91. doi: 10.1080/10298420290023954.
7
The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice.代谢型谷氨酸受体5拮抗剂MPEP可降低大鼠和小鼠对尼古丁的自我给药量。
Psychopharmacology (Berl). 2003 May;167(3):257-64. doi: 10.1007/s00213-003-1432-z. Epub 2003 Apr 8.
8
Critical role for ventral tegmental glutamate in preference for a cocaine-conditioned environment.腹侧被盖区谷氨酸在对可卡因条件化环境的偏好中起关键作用。
Neuropsychopharmacology. 2003 Jan;28(1):73-6. doi: 10.1038/sj.npp.1300011.
9
Low doses of dizocilpine block the development and subsequent expression of locomotor sensitization to nicotine in rats.低剂量的地佐环平可阻断大鼠对尼古丁运动致敏的发展及随后的表达。
Psychopharmacology (Berl). 2002 Jun;161(4):370-8. doi: 10.1007/s00213-002-1015-4. Epub 2002 Apr 20.
10
Role of nitric oxide synthase inhibitors and NMDA receptor antagonist in nicotine-induced behavioral sensitization in the rat.一氧化氮合酶抑制剂和NMDA受体拮抗剂在尼古丁诱导的大鼠行为敏化中的作用。
Eur J Pharmacol. 2002 May 17;443(1-3):119-24. doi: 10.1016/s0014-2999(02)01582-0.

N-甲基-D-天冬氨酸受体拮抗剂在尼古丁耐受、敏感化及身体依赖性中的作用：一项临床前综述

The role of NMDA receptor antagonists in nicotine tolerance, sensitization, and physical dependence: a preclinical review.

作者信息

Jain Raka, Mukherjee Kaushiki, Balhara Yatan Pal Singh

机构信息

National Drug Dependence Treatment Centre and Department of Psychiatry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, Pin 110029, India.

出版信息

Yonsei Med J. 2008 Apr 30;49(2):175-88. doi: 10.3349/ymj.2008.49.2.175.

DOI:10.3349/ymj.2008.49.2.175
PMID:18452252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2615322/
Abstract

Nicotine, the primary psychoactive component of tobacco products, produces diverse neurophysiological, motivational, and behavioral effects through several brain regions and neurochemical pathways. Various neurotransmitter systems have been explored to understand the mechanisms behind nicotine tolerance, dependence, and withdrawal. Recent evidence suggests that glutamate neurotransmission has an important role in this phenomenon. The aim of the present review is to discuss preclinical findings concerning the role of N-methyl-D-aspartate (NMDA) receptor neurotransmission in mediating the behavioral effects of nicotine, tolerance, sensitization, dependence, and withdrawal. Based on preclinical findings, it is hypothesized that NMDA receptors mediate the common adaptive processes that are involved in the development, maintenance, and expression of nicotine addiction. Modulation of glutamatergic neurotransmission with NMDA receptor antagonists may prove to be useful in alleviating the symptoms of nicotine abstinence and facilitate tobacco-smoking cessation.

摘要

尼古丁是烟草制品中的主要精神活性成分，它通过多个脑区和神经化学途径产生多种神经生理、动机和行为效应。人们已经探索了各种神经递质系统，以了解尼古丁耐受性、依赖性和戒断背后的机制。最近的证据表明，谷氨酸能神经传递在这一现象中起重要作用。本综述的目的是讨论关于N-甲基-D-天冬氨酸（NMDA）受体神经传递在介导尼古丁的行为效应、耐受性、敏化、依赖性和戒断方面作用的临床前研究结果。基于临床前研究结果，推测NMDA受体介导了参与尼古丁成瘾的发生、维持和表现的常见适应性过程。用NMDA受体拮抗剂调节谷氨酸能神经传递可能被证明有助于减轻尼古丁戒断症状并促进戒烟。