Shibata Eri, Sasaki Makoto, Tohyama Koujiro, Otsuka Kotaro, Endoh Jin, Terayama Yasuo, Sakai Akio
Department of Neuropsychiatry, Iwate Medical University School of Medicine, Morioka, Japan.
Biol Psychiatry. 2008 Sep 1;64(5):401-6. doi: 10.1016/j.biopsych.2008.03.021. Epub 2008 May 1.
We investigated alterations in the substantia nigra pars compacta (SNc) and locus ceruleus (LC) in schizophrenic and depressive patients by using a neuromelanin-sensitive magnetic resonance imaging (MRI) technique that enables direct visualization of these nuclei and examined whether this technique could distinguish between these disorders and healthy subjects.
Using a neuromelanin-sensitive T1-weighted MRI technique, we examined 20 schizophrenia patients, 18 depressive patients, and 34 healthy control subjects. The signal intensities of the areas corresponding to the SNc and LC were measured, and the contrast ratios (CR) to the adjacent white matter were calculated.
The CR of the SNc was significantly higher in schizophrenic patients (22.6 +/- 5.6) than in depressive patients (19.2 +/- 4.7) and healthy control subjects (19.6 +/- 3.8), whereas the CR of the LC in depressive patients (7.7 +/- 2.4) was significantly lower than that in healthy control subjects (11.0 +/- 3.9) and schizophrenic patients (10.0 +/- 3.1). Further, the difference in the CR between the SNc and LC was significantly greater in schizophrenic patients (12.6 +/- 6.7) than in control subjects (8.6 +/- 4.1).
Neuromelanin-sensitive MRI enables visualization of alterations in the SNc and LC that are observed in schizophrenia and depression.
我们通过使用一种对神经黑色素敏感的磁共振成像（MRI）技术来研究精神分裂症患者和抑郁症患者黑质致密部（SNc）和蓝斑（LC）的变化，该技术能够直接观察这些核团，并检查该技术是否能够区分这些疾病与健康受试者。
我们使用对神经黑色素敏感的T1加权MRI技术，检查了20名精神分裂症患者、18名抑郁症患者和34名健康对照受试者。测量了与SNc和LC相对应区域的信号强度，并计算了与相邻白质的对比率（CR）。
精神分裂症患者SNc的CR（22.6±5.6）显著高于抑郁症患者（19.2±4.7）和健康对照受试者（19.6±3.8），而抑郁症患者LC的CR（7.7±2.4）显著低于健康对照受试者（11.0±3.9）和精神分裂症患者（10.0±3.1）。此外，精神分裂症患者SNc和LC之间CR的差异（12.6±6.7）显著大于对照受试者（8.6±4.1）。
对神经黑色素敏感的MRI能够观察到精神分裂症和抑郁症中SNc和LC的变化。
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