Bogorodskaia E M, Antonova N V, Perel'man M I, Puchkov K G, Ivanushkina T N
Probl Tuberk Bolezn Legk. 2008(3):3-10.
to develop a procedure for calculating needs for antituberculous drugs (ATD).
A unified E-form (UEF) was developed as an "Excel" file with the underlying invariable formulas and coefficients for the computer-based calculation of ATD needs in any subject of the Russian Federation. The needs were estimated using the average number of tablets (capsules, vials) of each ATD required per man/course, by taking into account the conventional chemotherapy regimens, the duration of chemoprophylaxis, antirecurrent courses, ATD test therapy, a treatment regimen for complications due to BCG vaccination. Information on the inventory of ATDs at the end of the previous year and their estimated deliveries from various sources was additionally considered. Data to be filled in the UEF were obtained from the reporting documents: 1) TB Form No. 2 "Information on patients registered for treatment" approved by Order No. 50 "On Consummation of Recording and Reporting Documents as to Tuberculosis Monitoring" issued by the Ministry of Health of the Russian Federation on February 13, 2002; 2) Form No. 030-4/y "Tuberculosis Patient Follow-Up Schedule"; and 3) Form No. 33 "Information on Patients with Tuberculosis" approved by Regulation No. 80 issued by the Russian Statistics Agency on November 11, 2005. The filled-in UEFs were obtained from 82 subjects of the Russian Federation.
among all the contingents of antituberculosis dispensaries, who were given ATDs, the absolute majority was the persons receiving chemoprophylaxis. Only 18.3% received chemotherapy for active tuberculosis. Of them, 56.8 and 15.3% were treated in accordance with chemotherapy regimens 1 and 3, respectively. The regimes (2B and 4) using second-line agents were given least frequently (7.1 and 7.1%, respectively). Comparing the data from Form No. 33 and those obtained on filling in UEF showed with a fair degree of assurance that the treatment of patients with a chronic tuberculous process had been incompletely registered. Personified registration of patients with multidrug Mycobacterium tuberculosis resistance should be performed in order to have objective information on the scope of required medical aid and the real calculation of needs for second-line ATDs. For unified calculation of needs for ATDs for chemotherapy, it is necessary to introduce a standardized approach to its performance at different dispensaries. By taking into account that ATDs are purchased and dispensed free of change, one should have a responsible attitude to consuming drugs, determining indications for their usage, and filling the UEF. TB Form No. 2 "Information on patients registered for treatment" and Register No, 03-TB/y "Register of patients with tuberculosis" should be improved, by adding data on the number of patients receiving chemoprophylaxis, antirecurrent courses, test therapy, and treatment of complications due to BCG vaccination.
制定一种计算抗结核药物（ATD）需求的方法。
开发了一个统一的电子表格（UEF），它是一个“Excel”文件，带有固定的公式和系数，用于在计算机上计算俄罗斯联邦任何地区的ATD需求。通过考虑常规化疗方案、化学预防持续时间、抗复发疗程、ATD试验性治疗、卡介苗接种并发症的治疗方案，使用每人/疗程所需每种ATD的平均片剂（胶囊、小瓶）数量来估算需求。此外，还考虑了上一年年底ATD库存信息及其来自各种来源的预计交付量。填写UEF所需的数据来自报告文件：1）俄罗斯联邦卫生部2002年2月13日第50号命令“关于完善结核病监测记录和报告文件”批准的第2号结核病表格“治疗登记患者信息”；2）030 - 4/y号表格“结核病患者随访时间表”；3）俄罗斯统计机构2005年11月11日第80号条例批准的第33号表格“结核病患者信息”。填写好的UEF来自俄罗斯联邦的82个地区。
在所有接受ATD的结核病防治所人员中，绝大多数是接受化学预防的人员。只有18.3%的人接受活动性结核病化疗。其中，分别有56.8%和15.3%的人按照化疗方案1和3进行治疗。使用二线药物的方案（2B和4）使用频率最低（分别为7.1%和7.1%）。比较第33号表格的数据和填写UEF时获得的数据，可以有一定把握地看出，慢性结核病程患者的治疗登记不完整。应对耐多药结核分枝杆菌患者进行个体化登记，以便获得有关所需医疗救助范围的客观信息，并实际计算二线ATD的需求。为了统一计算化疗用ATD的需求，有必要在不同的防治所引入标准化的计算方法。考虑到ATD是免费采购和分发的，人们应该对药物消费、确定用药指征以及填写UEF持负责任的态度。应改进第2号结核病表格“治疗登记患者信息”和03 - TB/y号登记册“结核病患者登记册”，增加接受化学预防、抗复发疗程、试验性治疗以及卡介苗接种并发症治疗的患者人数数据。
