Serdiuk G V, Selivanov E V, Barkagan Z S
Klin Lab Diagn. 2008 Mar(3):38-9.
According to the recent data, the determination of the higher titer of antibodies to beta2-glycoprotein-I (beta2-GP-I) that is included in a complex compound with negative phospholipid membranes determinates the thrombogenicity in antiphospholipid syndrome (APS). To specify this regularity, the authors examined 86 patients with primary APS and 20 patients with venous and arterial thrombosis without APS. With increased beta2-GP-I antibody levels, the incidence of thrombotic events was established to w significantly higher than in APS without the increased titer of beta2-GP-I antibodies. In primary APS-associated persistent miscarriage, the increased titer of beta2-GP-I is much more infrequently encountered.
根据最近的数据，与阴性磷脂膜形成复合化合物的β2-糖蛋白-I（β2-GP-I）抗体滴度升高决定了抗磷脂综合征（APS）的血栓形成倾向。为明确这一规律，作者检查了86例原发性APS患者和20例无APS的静脉和动脉血栓形成患者。随着β2-GP-I抗体水平升高，血栓事件的发生率被确定显著高于β2-GP-I抗体滴度未升高的APS患者。在原发性APS相关的习惯性流产中，β2-GP-I滴度升高的情况则更为少见。
