Yang Jean Yee Hwa
School of Mathematics and Statistics, University of Sydney, New South Wales, Australia.
Methods Mol Med. 2008;141:71-85.
The rapid increase in the use of microarray studies has generated many questions on how to plan and design experiments that will effectively utilize this technology. Investigators often require answers to questions relating to microarray platforms, RNA samples, options for replication, allocation of samples to arrays, sample sizes, appropriate downstream analysis, and many others. Careful consideration of these issues is critical to ensure the efficiency and reliability of the actual microarray experiments, and will assist in enhancing interpretability of the experimental results.
微阵列研究应用的迅速增加引发了许多关于如何规划和设计实验以有效利用这项技术的问题。研究人员常常需要解答与微阵列平台、RNA样本、重复选项、样本在阵列上的分配、样本量、合适的下游分析等相关的问题。仔细考虑这些问题对于确保实际微阵列实验的效率和可靠性至关重要，并且将有助于增强实验结果的可解释性。
