提高DNA微阵列的可靠性和性能。

Improving reliability and performance of DNA microarrays.

作者信息

Sievertzon Maria, Nilsson Peter, Lundeberg Joakim

机构信息

Royal Institute of Technology, AlbaNova University Center, KTH Genome Center, Department of Biotechnology, S-106 91 Stockholm, Sweden.

出版信息

Expert Rev Mol Diagn. 2006 May;6(3):481-92. doi: 10.1586/14737159.6.3.481.

DOI:10.1586/14737159.6.3.481

PMID:16706748

Abstract

A great many platforms and versions of the microarray technology, with different characteristics and applications, have been developed. This review will describe some key issues in reliability and performance with the two most commonly used platforms for gene expression analysis, in situ-synthesized oligonucleotide microarrays or GeneChips and spotted microarrays. Some recent advances and new applications within the field will be mentioned briefly.

摘要

现已开发出大量具有不同特性和应用的微阵列技术平台及版本。本综述将描述基因表达分析中最常用的两种平台，即原位合成寡核苷酸微阵列或基因芯片以及点样微阵列在可靠性和性能方面的一些关键问题。还将简要提及该领域的一些最新进展和新应用。