Rajeshwari K, Gogia S
Department of Pediatrics, Maulana Azad Medical College, New Delhi 110002, India.
Trop Doct. 2008 Apr;38(2):101-2. doi: 10.1258/td.2007.060019.
We report on the clinical spectrum of chronic liver disease (CLD) in children presenting to a tertiary level teaching hospital. Children aged <14 years with suspected CLD presenting to the paediatric gastroenterology department of Maulana Azad Medical College between January 1999 and December 2004, were prospectively studied. They were all given liver function tests, abdominal ultrasonography, endoscopy, viral markers and were checked for Wilson's disease, autoimmune hepatitis and liver biopsy wherever feasible. Other tests for metabolic liver diseases were done when indicated. CLD was diagnosed in 174 children over the six-year period. Cryptogenic cirrhosis was the most common entity, followed by hepatitis B-induced liver disease and Wilson's disease. Most patients presented late with evident portal hypertension.
我们报告了一家三级教学医院收治的儿童慢性肝病（CLD）的临床谱。对1999年1月至2004年12月间就诊于莫拉纳·阿扎德医学院儿科胃肠病科、年龄小于14岁且疑似患有CLD的儿童进行了前瞻性研究。他们均接受了肝功能检查、腹部超声检查、内镜检查、病毒标志物检测，并在可行的情况下检查是否患有威尔逊病、自身免疫性肝炎以及进行肝活检。如有指征，则进行其他代谢性肝病的检查。在这六年期间，共诊断出174例儿童CLD。隐源性肝硬化是最常见的类型，其次是乙型肝炎所致肝病和威尔逊病。大多数患者就诊时已出现明显的门静脉高压。
