Beylot J, Veyret V, Vallat I, Longy M, Moretti G
Sem Hop. 1976 Feb 23;52(8):489-96.
In spite of possible toxicity streptozotocin now appears to be the best treatment for malignant islet cell tumour with liver metastases, i.e. inoperable tumours with a poor prognosis either due to extension of the tumour itself or due to hypoglycemic attacks. Out of about 60 patients thus treated, 1 to 2 years survival were obtained. 22 out of 52 patients reported by Broder and Carter are still alive and one may estimate the overall percentage of favourable results at 65%. On the other hand out of another 100 patients treated elsewhere with this antineoplastic agent, only a few cases of carcinoid tumour gave encouraging results. The course of the others was not modified significantly.
尽管链脲佐菌素可能具有毒性，但目前它似乎是治疗伴有肝转移的恶性胰岛细胞瘤的最佳疗法，即因肿瘤本身扩散或因低血糖发作而无法手术且预后不良的肿瘤。在接受如此治疗的约60例患者中，获得了1至2年的生存期。布罗德和卡特报告的52例患者中有22例仍然存活，人们可以估计总体良好结果的百分比为65%。另一方面，在其他地方用这种抗肿瘤药治疗的另外100例患者中，只有少数类癌肿瘤病例取得了令人鼓舞的结果。其他患者的病程没有明显改变。
