对于白血病患儿，脑脊液蛋白测量并无必要。

Measurement of cerebrospinal fluid protein is unnecessary in children with leukemia.

作者信息

Barber Ashley, Lovato James, Hill Garick, McLean Thomas W

机构信息

Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, NC 27157, USA.

出版信息

Pediatr Blood Cancer. 2008 Sep;51(3):428-30. doi: 10.1002/pbc.21586.

DOI:10.1002/pbc.21586

PMID:18454465

Abstract

To determine the incidence and importance of abnormal cerebrospinal fluid (CSF) protein in children with acute leukemia, we performed a retrospective chart review. On 160 pediatric patients a total of 2,172 LPs were performed (median per patient = 15; range 1-38). Overall, 314 (14%) of CSF protein measurements were abnormal: 141 (7%) were abnormally low (<15 mg/dL) and 158 (7%) were abnormally high (>45 mg/dL). In no case did an abnormal CSF protein impact patient management. We conclude that routine measurement of CSF protein is not indicated in children with acute leukemia.

摘要

为了确定急性白血病患儿脑脊液（CSF）蛋白异常的发生率及其重要性，我们进行了一项回顾性病历审查。对160例儿科患者共进行了2172次腰椎穿刺（LPs）（每位患者的中位数为15次；范围为1 - 38次）。总体而言，314次（14%）脑脊液蛋白测量结果异常：141次（7%）异常偏低（<15mg/dL），158次（7%）异常偏高（>45mg/dL）。脑脊液蛋白异常从未影响患者的治疗管理。我们得出结论，急性白血病患儿无需常规检测脑脊液蛋白。