Devor E J, Cloninger C R, Hoffman P L, Tabakoff B
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Alcohol Alcohol Suppl. 1991;1:157-60.
The stimulated activity of platelet adenylate cyclase (AC) has been shown to be significantly lower among alcoholics compared with controls. In this report we demonstrate that stimulated platelet AC activity is under the control of a single major gene locus. Thus a sensitive biological indicator of alcoholism has been shown to be highly heritable.
与对照组相比，酗酒者血小板腺苷酸环化酶（AC）的刺激活性显著降低。在本报告中，我们证明刺激后的血小板AC活性受单一主要基因位点的控制。因此，酗酒的一种敏感生物学指标已被证明具有高度遗传性。
