Levy A D, Murphy J M, McBride W J, Lumeng L, Li T K
Department of Psychiatry, Indiana University School of Medicine, Indianapolis.
Alcohol Alcohol Suppl. 1991;1:417-20.
The effects of dopamine antagonists microinjected into the nucleus accumbens (Acb) on alcohol-drinking behavior were studied in the selectively bred alcohol-preferring (P) line of rats. P female rats (N = 8) were given access to food and water ad lib, while availability of a 10% (v/v) ethanol solution was limited to 1 hr/day. After implantation of guide cannulas bilaterally into the Acb and recovery from surgery, the rats were microinjected with either the D1 antagonist SCH 23390 (0.1 to 2.0 micrograms/side), the D2 antagonist sulpiride (0.1 to 2.0 micrograms/side) or vehicle, and ethanol intake was monitored. The D1 antagonist SCH 23390 had little effect on alcohol intake although the 0.5 ug/side dose produced a small increase which was not statistically significant. The D2 antagonist sulpiride increased, in a dose dependent manner, the intake of ethanol to as high as 215% of control values (F(4,28) = 39.9; p < 0.001). Additional experiments indicated that the 2.0 micrograms/side dose of sulpiride did not alter the consumption of a 14% glucose nor a 0.25% saccharin solution. These data suggest that D2 receptors in the Acb are important in the regulation of alcohol drinking by the P line of rats.
在选择性培育的嗜酒（P）品系大鼠中，研究了向伏隔核（Acb）微量注射多巴胺拮抗剂对饮酒行为的影响。给8只P品系雌性大鼠随意提供食物和水，而10%（v/v）乙醇溶液的供应时间限制为每天1小时。在双侧植入Acb的引导套管并从手术中恢复后，给大鼠微量注射D1拮抗剂SCH 23390（0.1至2.0微克/侧）、D2拮抗剂舒必利（0.1至2.0微克/侧）或溶剂，然后监测乙醇摄入量。D1拮抗剂SCH 23390对酒精摄入量几乎没有影响，尽管0.5微克/侧的剂量有小幅增加，但无统计学意义。D2拮抗剂舒必利以剂量依赖的方式将乙醇摄入量增加到对照值的215%（F(4,28) = 39.9；p < 0.001）。额外的实验表明，2.0微克/侧剂量的舒必利不会改变14%葡萄糖溶液或0.25%糖精溶液的消耗量。这些数据表明，Acb中的D2受体在P品系大鼠饮酒行为的调节中起重要作用。
