Caswell Patrick, Norman Jim
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
Trends Cell Biol. 2008 Jun;18(6):257-63. doi: 10.1016/j.tcb.2008.03.004. Epub 2008 May 2.
Early studies describing the endocytic-exocytic cycling of integrins prompted proposals that this process regulates cell migration. However, it is only relatively recently that more detailed descriptions of the molecular machinery responsible for directing integrin trafficking have enabled us to properly address the role of these events during the various modes of cell migration. Here, we review recent advances in our understanding of the protein complexes and signallosomes controlling integrin trafficking, and we describe how these influence cell migration and signalling events downstream of integrin engagement. Furthermore, we consider recent evidence for integrin trafficking during the invasive migration of cancer cells through 3D microenvironments, and conclude with a discussion of the use of novel photoactivatable integrin probes to visualize these processes.
早期关于整合素内吞 - 外排循环的研究促使人们提出这一过程调节细胞迁移的观点。然而，直到最近，对负责指导整合素运输的分子机制的更详细描述，才使我们能够恰当地探讨这些事件在细胞迁移的各种模式中的作用。在这里，我们回顾了我们对控制整合素运输的蛋白质复合物和信号小体的理解的最新进展，并描述了这些如何影响整合素结合下游的细胞迁移和信号事件。此外，我们考虑了癌细胞在通过三维微环境进行侵袭性迁移过程中整合素运输的最新证据，并以讨论使用新型光激活整合素探针来可视化这些过程作为总结。
