Skinner-Adams T S, McCarthy J S, Gardiner D L, Andrews K T
University of Queensland, Brisbane, Australia.
Trends Parasitol. 2008 Jun;24(6):264-71. doi: 10.1016/j.pt.2008.03.008. Epub 2008 May 2.
The global epidemiology of HIV/AIDS and malaria overlap because a significant number of HIV-infected individuals live in regions with different levels of malaria transmission. Although the consequences of co-infection with HIV and malaria parasites are not fully understood, available evidence suggests that the infections act synergistically and together result in worse outcomes. The importance of understanding chemotherapeutic interactions during malaria and HIV co-infection is now being recognized. We know that some antimalarial drugs have weak antiretroviral effects; however, recent studies have also demonstrated that certain antiretroviral agents can inhibit malaria-parasite growth. Here, we discuss recent findings on the impact of HIV/AIDS and malaria co-infection and the possible roles of chemotherapy in improving the treatment of these diseases.
全球范围内，艾滋病病毒/艾滋病（HIV/AIDS）与疟疾的流行病学情况相互重叠，因为大量感染HIV的个体生活在疟疾传播程度各异的地区。尽管HIV与疟原虫合并感染的后果尚未完全明确，但现有证据表明，这两种感染具有协同作用，共同导致更糟糕的结果。目前，人们已经认识到了解疟疾与HIV合并感染期间化疗相互作用的重要性。我们知道一些抗疟药物具有微弱的抗逆转录病毒作用；然而，近期研究也表明，某些抗逆转录病毒药物能够抑制疟原虫生长。在此，我们将讨论有关HIV/AIDS与疟疾合并感染影响的最新研究发现，以及化疗在改善这些疾病治疗效果方面可能发挥的作用。
