脆性X综合征婴儿的对比度检测
Contrast detection in infants with fragile X syndrome.
作者信息
Farzin F, Whitney D, Hagerman R J, Rivera S M
机构信息
Department of Psychology, University of California, Davis, CA 95618, USA.
出版信息
Vision Res. 2008 Jun;48(13):1471-8. doi: 10.1016/j.visres.2008.03.019. Epub 2008 May 23.
Abstract
Studies have reported that a selective deficit in visual motion processing is present in certain developmental disorders, including Williams syndrome and autism. More recent evidence suggests a visual motion impairment is also present in adults with fragile X syndrome (FXS), the most common form of inherited mental retardation. The goal of the current study was to examine low-level cortical visual processing in infants diagnosed with FXS in order to explore the developmental origin of this putative deficit. We measured contrast detection of first-order (luminance-defined) and second-order (contrast-defined) gratings at two levels of temporal frequency, 0 Hz (static) and 4 Hz (moving). Results indicate that infants with FXS display significantly higher detection thresholds only for the second-order, moving stimuli compared to mental age-matched typically developing controls.
摘要
研究报告称，在某些发育障碍中存在视觉运动处理方面的选择性缺陷，包括威廉姆斯综合征和自闭症。最近的证据表明，患有脆性X综合征（FXS）的成年人也存在视觉运动障碍，脆性X综合征是遗传性智力障碍最常见的形式。本研究的目的是检查被诊断为FXS的婴儿的低水平皮质视觉处理，以探索这种假定缺陷的发育起源。我们在两个时间频率水平，即0Hz（静态）和4Hz（动态）下测量了一阶（亮度定义）和二阶（对比度定义）光栅的对比度检测。结果表明，与心理年龄匹配的典型发育对照组相比，患有FXS的婴儿仅在二阶动态刺激方面表现出明显更高的检测阈值。
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