Lin Ben-Lan, Shen Xiao-Dong, Cui Sheng
College of Material Science and Technology, Nanjing, 210009, People's Republic of China.
Biomed Mater. 2007 Jun;2(2):132-4. doi: 10.1088/1748-6041/2/2/011. Epub 2007 May 3.
The purpose of this study was to prepare human serum albumin (HSA) microspheres with Fe(3)O(4) magnetic nanoparticles for tumor target therapy. Fe(3)O(4) was obtained by liquid-phase coprecipitation; HSA-coated magnetic particles were attained by solidification at high temperature. The result was that nanosized Fe(3)O(4) is a cubic crystal by XRD and the average size is 18.7 nm; the average size of HSA-coated magnetic particles is 341 nm. Fe(3)O(4) magnetic nanoparticles coated with HSA can be used for targeted-drug carriers with target-orientation and sustained-release properties.
本研究的目的是制备具有Fe(3)O(4)磁性纳米粒子的人血清白蛋白（HSA）微球用于肿瘤靶向治疗。通过液相共沉淀法获得Fe(3)O(4)；通过高温固化获得HSA包被的磁性颗粒。结果表明，通过X射线衍射（XRD）可知纳米级Fe(3)O(4)为立方晶体，平均粒径为18.7nm；HSA包被的磁性颗粒的平均粒径为341nm。HSA包被的Fe(3)O(4)磁性纳米粒子可用于具有靶向性和缓释特性的靶向药物载体。
