Kim T H, Jiang H L, Nah J W, Cho M H, Akaike T, Cho C S
School of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea.
Biomed Mater. 2007 Sep;2(3):S95-100. doi: 10.1088/1748-6041/2/3/S02. Epub 2007 Jul 30.
Chitosan has been investigated as a non-viral vector because it has several advantages such as biocompatibility, biodegradability and low toxicity with high cationic potential. However, the low specificity and low transfection efficiency of chitosan need to be solved prior to clinical application. In this paper, we focused on the galactose or mannose ligand modification of chitosan for enhancement of cell specificity and transfection efficiency via receptor-mediated endocytosis in vitro and in vivo.
壳聚糖已被作为一种非病毒载体进行研究，因为它具有生物相容性、生物可降解性以及低毒性和高阳离子潜力等多种优点。然而，壳聚糖的低特异性和低转染效率在临床应用前需要解决。在本文中，我们聚焦于壳聚糖的半乳糖或甘露糖配体修饰，以通过体外和体内受体介导的内吞作用提高细胞特异性和转染效率。
