中枢胃饥饿素的复杂性
The CAMplexities of central ghrelin.
作者信息
Sleeman Mark W, Latres Esther
机构信息
Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
出版信息
Cell Metab. 2008 May;7(5):361-2. doi: 10.1016/j.cmet.2008.04.009.
PMID:18460326
Abstract
The gut hormone ghrelin is known to activate hypothalamic AMPK, a crucial metabolic sensor controlling energy balance. In this issue of Cell Metabolism, Anderson et al. (2008) show that CaMKK2 mediates this effect by forming a unique complex of AMPKalpha/beta with acetyl-CoA carboxylase (ACC) in a pathway distinct from the more established AMP/LKB1 pathway.
摘要
已知肠道激素胃饥饿素可激活下丘脑的AMPK，AMPK是控制能量平衡的关键代谢传感器。在本期《细胞代谢》中，安德森等人（2008年）表明，CaMKK2通过在一条不同于更为人熟知的AMP/LKB1途径的通路中，使AMPKα/β与乙酰辅酶A羧化酶（ACC）形成独特的复合物来介导这一效应。
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