Walter H, Wolf R C
Klinik für Psychiatrie und Psychotherapie, Friedrich Wilhelms Universität Bonn, Germany.
Fortschr Neurol Psychiatr. 2008 May;76 Suppl 1:S16-23. doi: 10.1055/s-2008-1038130.
Working memory (WM) deficits are core symptoms of cognitive impairment in schizophrenia. WM-models serve as theoretical and empirical framework for the investigation of cognitive dysfunction as well as of schizophrenic phenomenology. Behavioral and functional neuroimaging data support the concept of a supramodal WM-deficit in schizophrenia, associated with the functional integrity of prefrontal regions. This review provides a short overview of WM-dysfunction in schizophrenia as well as its impact on psychopathology. Furthermore, the relationship of WM-associated cerebral activation and psychopathological symptoms is illustrated. Currently available studies on WM-function and psychopathology in schizophrenia obtained rather heterogeneous results, although disorganisation and negative symptoms may be closely linked to prefrontal regions. The investigation of WM-function in schizophrenic subsyndromes with functional neuroimaging techniques still remains a clinical and scientific desideratum.
工作记忆（WM）缺陷是精神分裂症认知障碍的核心症状。WM模型为研究认知功能障碍以及精神分裂症现象学提供了理论和实证框架。行为和功能神经影像学数据支持精神分裂症存在超模态WM缺陷的概念，这与前额叶区域的功能完整性相关。本综述简要概述了精神分裂症中的WM功能障碍及其对精神病理学的影响。此外，还阐述了与WM相关的大脑激活与精神病理症状之间的关系。目前关于精神分裂症中WM功能和精神病理学的研究结果相当不一致，尽管紊乱和阴性症状可能与前额叶区域密切相关。运用功能神经影像学技术对精神分裂症亚综合征的WM功能进行研究仍然是临床和科学上的迫切需求。
