卡泊三醇倍他米松二丙酸酯头皮制剂治疗头皮银屑病有效且耐受性良好：一项II期研究。
Calcipotriol plus betamethasone dipropionate scalp formulation is effective and well tolerated in the treatment of scalp psoriasis: a phase II study.
作者信息
Buckley Colin, Hoffmann Vibeke, Shapiro Jerry, Saari Seppo, Cambazard Frederic, Milsgaard Mette
机构信息
Department of Dermatology, Waterford Regional Hospital Ardkeen, Waterford, Ireland.
出版信息
Dermatology. 2008;217(2):107-13. doi: 10.1159/000130425. Epub 2008 May 8.
BACKGROUND
There is a need for more effective therapy for scalp psoriasis.
OBJECTIVE
To assess the efficacy and safety of a 2-compound scalp formulation including calcipotriol and betamethasone dipropionate in the treatment of scalp psoriasis.
METHODS
Patients (n = 218) with scalp psoriasis were randomized to treatment with the 2-compound scalp formulation (n = 108) or betamethasone dipropionate in the same vehicle (n = 110). The treatments were applied once daily on the scalp for up to 8 weeks.
RESULTS
The 2-compound scalp formulation showed a significantly higher efficacy than betamethasone dipropionate on the total sign score at the end of treatment (p = 0.042) and after 2 weeks (p = 0.005).
CONCLUSION
The calcipotriol plus betamethasone dipropionate scalp formulation was superior to betamethasone dipropionate in the same vehicle when used once daily for up to 8 weeks in the treatment of scalp psoriasis.
背景
头皮银屑病需要更有效的治疗方法。
目的
评估一种包含卡泊三醇和二丙酸倍他米松的复方头皮制剂治疗头皮银屑病的疗效和安全性。
方法
将218例头皮银屑病患者随机分为两组，分别接受复方头皮制剂治疗（n = 108）或接受相同赋形剂的二丙酸倍他米松治疗（n = 110）。治疗方法为每天在头皮上涂抹一次，持续8周。
结果
在治疗结束时（p = 0.042）和2周后（p = 0.005），复方头皮制剂在总体征评分上显示出比二丙酸倍他米松显著更高的疗效。
结论
在头皮银屑病治疗中，每天使用一次卡泊三醇加二丙酸倍他米松头皮制剂，持续8周，其疗效优于相同赋形剂的二丙酸倍他米松。
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