Zhang Ming, Surles James G
Department of Speech Language and Hearing Sciences, Texas Tech University - Health Sciences Center, Lubbock, Texas 79430, USA.
Neuroreport. 2008 May 28;19(8):855-9. doi: 10.1097/WNR.0b013e3282ff84e8.
The aim of this report is to show the effects of voltage changes on stereocilia stiffness in mammalian outer hair cells (OHCs). With the OHC cuticular plate anchored at a microchamber tip, step voltage commands drove an OHC inside the microchamber to move freely while stereocilia were oscillated at 510 Hz by a constant fluid-jet force. With basolateral OHC depolarized and shortened, the amplitude of stereocilia motion was increased, suggesting a decrease in stereocilia stiffness. Such a decrease in stiffness may serve as an important adjusting factor inside the cochlear amplifying loop.
本报告的目的是展示电压变化对哺乳动物外毛细胞（OHC）中静纤毛刚度的影响。将OHC角质板固定在微腔尖端，阶跃电压指令驱使微腔内的OHC自由移动，同时静纤毛在恒定的流体喷射力作用下以510 Hz振荡。随着OHC基底外侧去极化并缩短，静纤毛运动的幅度增加，表明静纤毛刚度降低。这种刚度的降低可能是耳蜗放大回路中的一个重要调节因素。
