Akaza Eriko, Mori Ryusaburo, Yuzawa Mitsuko
Department of Ophthalmology, School of Medicine, Nihon University, Japan.
Retina. 2008 May;28(5):717-22. doi: 10.1097/IAE.0b013e31816577cb.
This study evaluated the results of photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV) 24 months or more after treatment.
The study involved 47 eyes of 47 patients with PCV followed for 24 months or more after the first PDT. Fundus appearance, indocyanine green angiographic findings, and visual acuity (VA) were compared before PDT, and then at 3 months, 12 months, and the final visit after the first PDT.
At the final visit, VA was preserved or improved in 37 (79%) of the 47 eyes. Recurrence of polypoidal lesions was noted in 30 eyes (64%). An abnormal branching vascular network persisted in all subjects. In 26 of the 30 eyes exhibited recurrence of polypoidal lesions, which appeared in the periphery of the expanded abnormal branching vascular network.
Patients with PCV need to be followed for long periods of time after PDT because of the high incidence of polypoidal lesion recurrence. However, since polypoidal lesions often recur outside the fovea, and thus have little effect on VA, PDT can be expected to exert long-term efficacy in treating PCV.
本研究评估了光动力疗法（PDT）治疗息肉样脉络膜血管病变（PCV）24个月及更长时间后的效果。
该研究纳入了47例PCV患者的47只眼，在首次PDT后随访24个月及更长时间。比较了PDT前、首次PDT后3个月、12个月及最后一次随访时的眼底外观、吲哚菁绿血管造影结果和视力（VA）。
在最后一次随访时，47只眼中有37只（79%）的视力得以保留或提高。30只眼（64%）出现了息肉样病变复发。所有受试者均存在异常分支血管网。在30只出现息肉样病变复发的眼中，有26只出现在扩张的异常分支血管网周边。
由于息肉样病变复发率高，PCV患者在PDT后需要长期随访。然而，由于息肉样病变常发生在黄斑中心凹以外，因此对视力影响较小，预计PDT在治疗PCV方面可发挥长期疗效。
