Faia Lisa J, Pulido Jose S, Donaldson Mark J, Salomão Diva R, Cameron J Douglas, Mullan Brian, Gunduz Kaan
Department of Ophthalmology,, Mayo Clinic, Rochester, Minnesota, USA.
Retina. 2008 May;28(5):763-9. doi: 10.1097/IAE.0b013e3181631937.
To investigate the correlation between the clinical and light microscopic features of choroidal melanoma with combined PET/CT findings.
This is a retrospective interventional case series of 14 patients with choroidal melanoma referred to the vitreoretinal service at the Mayo Clinic, Rochester, MN. All underwent preoperative combined PET/CT scanning and enucleation. Standardized uptake values (SUV) were correlated with the clinical and light microscopic features of the choroidal melanomas.
All 14 eyes showed uptake. The mean patient age was 62 years (SD 12.5 years). The mean tumor thickness was 9.3 mm (range 3-23 mm). Histopathology showed choroidal melanoma in all with the following cell types: 6 mixed cell type, 7 spindle cell type, and 1 epithelioid cell type. The average of the SUV means was 3.7 (range 1.7-12.8). The individual SUV means were correlated with lesion thickness (r = 0.85; P < 0.01) and largest tumor basal diameter (r = 0.65; P = 0.01). Melanomas with focal necrosis (P = 0.03) and of the mixed cell type (P < 0.01) appeared to have higher SUV means.
The majority of the choroidal melanomas had low to medium mean SUVs. Lesion size accounted for a significant portion of the variation, though nonspecific necrosis and cell type were also associated with higher SUV means.
探讨脉络膜黑色素瘤的临床及光学显微镜特征与PET/CT联合检查结果之间的相关性。
这是一项回顾性干预性病例系列研究，纳入了14例转诊至明尼苏达州罗切斯特市梅奥诊所玻璃体视网膜科的脉络膜黑色素瘤患者。所有患者均接受了术前PET/CT联合扫描及眼球摘除术。将标准化摄取值（SUV）与脉络膜黑色素瘤的临床及光学显微镜特征进行相关性分析。
14只眼均显示有摄取。患者平均年龄为62岁（标准差12.5岁）。肿瘤平均厚度为9.3mm（范围3 - 23mm）。组织病理学检查显示所有病例均为脉络膜黑色素瘤，细胞类型如下：6例混合细胞型，7例梭形细胞型，1例上皮样细胞型。SUV平均值的平均数为3.7（范围1.7 - 12.8）。个体SUV平均值与病变厚度（r = 0.85；P < 0.01）及肿瘤最大基底直径（r = 0.65；P = 0.01）相关。伴有局灶性坏死的黑色素瘤（P = 0.03）及混合细胞型黑色素瘤（P < 0.01）的SUV平均值似乎更高。
大多数脉络膜黑色素瘤的平均SUV值为低至中等。病变大小占变异的很大一部分，尽管非特异性坏死和细胞类型也与较高的SUV平均值相关。
