果蝇幼虫肌肉中的一种环磷酸腺苷激活的钾离子通道在“笨蛋”突变体中持续被激活。
A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce.
作者信息
Delgado R, Hidalgo P, Diaz F, Latorre R, Labarca P
机构信息
Centro de Estudios Cientificos de Santiago, Chile.
出版信息
Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):557-60. doi: 10.1073/pnas.88.2.557.
Abstract
Single-channel recording from longitudinal ventrolateral Drosophila larval muscle reveals the presence of a potassium-selective channel that is directly and reversibly activated by cAMP in a dose-dependent fashion. Activation is specific and it cannot be mimicked by a series of agents that include AMP, cGMP, ATP, inositol trisphosphate, and Ca2+. Channel current records obtained from larval muscle in different dunce mutants possessing abnormally high levels of cAMP show that, in the mutants, the channel displays an increased probability of opening.
摘要
对果蝇幼虫纵向腹外侧肌肉进行单通道记录发现，存在一种钾离子选择性通道，该通道可被环磷酸腺苷（cAMP）以剂量依赖的方式直接且可逆地激活。这种激活具有特异性，一系列包括腺苷一磷酸（AMP）、环磷酸鸟苷（cGMP）、三磷酸腺苷（ATP）、肌醇三磷酸和钙离子（Ca2+）在内的物质都无法模拟这种激活作用。从具有异常高水平cAMP的不同迟钝突变体的幼虫肌肉中获得的通道电流记录表明，在这些突变体中，该通道开放的概率增加。
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本文引用的文献
1
The effect of sodium ions on the electrical activity of giant axon of the squid.钠离子对鱿鱼巨大轴突电活动的影响。
J Physiol. 1949 Mar 1;108(1):37-77. doi: 10.1113/jphysiol.1949.sp004310.
2
Isolation of the Drosophila melanogaster dunce chromosomal region and recombinational mapping of dunce sequences with restriction site polymorphisms as genetic markers.黑腹果蝇“笨蛋”染色体区域的分离以及以限制性位点多态性作为遗传标记对“笨蛋”序列进行重组定位。
Mol Cell Biol. 1984 Feb;4(2):358-67. doi: 10.1128/mcb.4.2.358-367.1984.
3
The automated analysis of data from single ionic channels.来自单个离子通道数据的自动化分析。
Pflugers Arch. 1982 Dec;395(4):331-40. doi: 10.1007/BF00580798.
4
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.用于从细胞和无细胞膜片进行高分辨率电流记录的改进膜片钳技术。
Pflugers Arch. 1981 Aug;391(2):85-100. doi: 10.1007/BF00656997.
5
Genetic modification of potassium channels in Drosophila Shaker mutants.果蝇Shaker突变体中钾通道的基因改造。
Nature. 1981;293(5829):228-30. doi: 10.1038/293228a0.
6
Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system.黑腹果蝇的笨蛋突变体：在环磷酸腺苷磷酸二酯酶酶系统中存在缺陷的突变体。
J Cell Biol. 1981 Jul;90(1):101-7. doi: 10.1083/jcb.90.1.101.
7
Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster.果蝇中因“笨蛋”突变导致的环磷酸腺苷磷酸二酯酶缺陷与学习有关。
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8
Genetic alteration of nerve membrane excitability in temperature-sensitive paralytic mutants of Drosophila melanogaster.
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9
Voltage-gated potassium channels in larval CNS neurons of Drosophila.果蝇幼虫中枢神经系统神经元中的电压门控钾通道。
J Neurosci. 1988 Jul;8(7):2556-70. doi: 10.1523/JNEUROSCI.08-07-02556.1988.
10
Single-channel analysis of four distinct classes of potassium channels in Drosophila muscle.果蝇肌肉中四种不同类型钾通道的单通道分析
J Neurosci. 1988 Dec;8(12):4765-79. doi: 10.1523/JNEUROSCI.08-12-04765.1988.
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