Delgado R, Hidalgo P, Diaz F, Latorre R, Labarca P
Centro de Estudios Cientificos de Santiago, Chile.
Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):557-60. doi: 10.1073/pnas.88.2.557.
Single-channel recording from longitudinal ventrolateral Drosophila larval muscle reveals the presence of a potassium-selective channel that is directly and reversibly activated by cAMP in a dose-dependent fashion. Activation is specific and it cannot be mimicked by a series of agents that include AMP, cGMP, ATP, inositol trisphosphate, and Ca2+. Channel current records obtained from larval muscle in different dunce mutants possessing abnormally high levels of cAMP show that, in the mutants, the channel displays an increased probability of opening.