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胰岛素对磷脂酰肌醇-3-激酶的激活是由A型和B型人胰岛素受体共同介导的。

Activation of phosphatidylinositol-3-kinase by insulin is mediated by both A and B human insulin receptor types.

作者信息

Carrascosa J M, Vogt B, Ullrich A, Häring H U

机构信息

Institut für Diabetesforschung, München, Germany.

出版信息

Biochem Biophys Res Commun. 1991 Jan 15;174(1):123-7. doi: 10.1016/0006-291x(91)90494-r.

DOI:10.1016/0006-291x(91)90494-r
PMID:1846534
Abstract

Activation of a phosphatidylinositol-3-kinase (PI-3-kinase) is one of the earliest consequences of insulin binding to the receptor. The human insulin receptor exists in two isoforms which differ in the length of the alpha-subunit (HIR-A = 719 aa, HIR-B = 731 aa). To test whether both isoforms transduce an insulin signal on PI-3-kinase we used rat-1-fibroblasts expressing HIR-A or HIR-B. We found that insulin stimulates 32P incorporation into PIP through both HIR-A and HIR-B to a similar extent (approx. 8-10 fold).

摘要

磷脂酰肌醇-3-激酶（PI-3-激酶）的激活是胰岛素与受体结合最早产生的结果之一。人胰岛素受体存在两种亚型，其α亚基长度不同（HIR-A = 719个氨基酸，HIR-B = 731个氨基酸）。为了检测这两种亚型是否都能在PI-3-激酶上转导胰岛素信号，我们使用了表达HIR-A或HIR-B的大鼠-1成纤维细胞。我们发现胰岛素通过HIR-A和HIR-B刺激32P掺入PIP的程度相似（约8-10倍）。

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引用本文的文献

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Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.胰岛素受体同工型A，一种在胎儿和癌细胞中新发现的高亲和力胰岛素样生长因子II受体。
Mol Cell Biol. 1999 May;19(5):3278-88. doi: 10.1128/MCB.19.5.3278.
2
Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: candidates for a signal transmitter defect causing insulin resistance of the skeletal muscle.2型（非胰岛素依赖型）糖尿病的发病机制：导致骨骼肌胰岛素抵抗的信号转导缺陷候选因素。
Diabetologia. 1993 Mar;36(3):176-82. doi: 10.1007/BF00399946.
3
Association of the insulin receptor and phosphatidylinositol 3-kinase requires a third component.
胰岛素受体与磷脂酰肌醇3激酶的结合需要第三种成分。
Biochem J. 1994 Jan 15;297 ( Pt 2)(Pt 2):335-42. doi: 10.1042/bj2970335.
4
Hyperinsulinemia is associated with altered insulin receptor mRNA splicing in muscle of the spontaneously obese diabetic rhesus monkey.高胰岛素血症与自发性肥胖糖尿病恒河猴肌肉中胰岛素受体mRNA剪接改变有关。
J Clin Invest. 1994 Sep;94(3):1289-96. doi: 10.1172/JCI117447.
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Modulation of insulin receptor signalling: significance of altered receptor isoform patterns and mechanism of hyperglycaemia-induced receptor modulation.胰岛素受体信号传导的调节：受体亚型模式改变的意义及高血糖诱导受体调节的机制
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