Genetic heterogeneity and trans regulators of gene expression.
作者信息
Bastone Laurel A, Putt Mary E, Ten Have Thomas R, Cheung Vivian G, Spielman Richard S
机构信息
Division of Biostatistics, Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA.
出版信息
BMC Proc. 2007;1 Suppl 1(Suppl 1):S80. doi: 10.1186/1753-6561-1-s1-s80. Epub 2007 Dec 18.
Abstract
Heterogeneity poses a challenge to linkage mapping. Here, we apply a latent class extension of Haseman-Elston regression to expression phenotypes with significant evidence of linkage to trans regulators in 14 large pedigrees. We test for linkage, accounting for heterogeneity, and classify individual families as "linked" and "unlinked" on the basis of their contribution to the overall evidence of linkage.
摘要
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