Department of Biochemistry, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
Genome Biol. 2008 Apr 30;9(4):216. doi: 10.1186/gb-2008-9-4-216.
The AAA+ superfamily is a large and functionally diverse superfamily of NTPases that are characterized by a conserved nucleotide-binding and catalytic module, the AAA+ module. Members are involved in an astonishing range of different cellular processes, attaining this functional diversity through additions of structural motifs and modifications to the core AAA+ module.
AAA+ 超家族是一个庞大且功能多样的 NTPase 超家族,其特征是具有保守的核苷酸结合和催化模块,即 AAA+ 模块。成员参与了令人惊讶的各种不同的细胞过程,通过添加结构基序和对核心 AAA+模块进行修饰来实现这种功能多样性。