强烈的肥厚状态会诱发兔心脏线粒体DNA快速突变吗？

Does strong hypertrophic condition induce fast mitochondrial DNA mutation of rabbit heart?

作者信息

Kim Taeho, Thu Vu Thi, Han Il-Yong, Youm Jae Boum, Kim Euiyong, Kang Sun Woo, Kim Yang Wook, Lee Jae Hwa, Joo Hyun

机构信息

Department of Physiology and Biophysics, School of Medicine, Inje University, Busan 614-735, Republic of Korea.

出版信息

Mitochondrion. 2008 Jun;8(3):279-83. doi: 10.1016/j.mito.2008.03.003. Epub 2008 Apr 1.

DOI:10.1016/j.mito.2008.03.003

PMID:18467192

Abstract

Homo- and heteroplasmic mitochondrial DNA (mtDNA) mutations were observed and identified in an isoproterenol-induced rabbit model of cardiac hypertrophy. Genes encoding proteins essential for catalyzing mitochondrial electron transfer and for generating the proton motive force, such as NADH dehydrogenases (ND2, ND3, ND4, and ND6), cytochrome b, and ATPase 8, showed increased susceptibility for mutation. Specifically, five mutations caused amino acid changes and were located in Complex I and Complex V gene clusters. To our knowledge, this is the first demonstration of a relationship between cardiac hypertrophy induced by a strong sympathetic load and rapid mtDNA mutations.

摘要

在异丙肾上腺素诱导的兔心脏肥大模型中观察并鉴定出了同质性和异质性线粒体DNA（mtDNA）突变。编码对催化线粒体电子传递和产生质子动力至关重要的蛋白质的基因，如NADH脱氢酶（ND2、ND3、ND4和ND6）、细胞色素b和ATP酶8，显示出对突变的易感性增加。具体而言，五个突变导致了氨基酸变化，且位于复合体I和复合体V基因簇中。据我们所知，这是首次证明强烈交感负荷诱导的心脏肥大与快速mtDNA突变之间的关系。