Lear T L, Bailey E
M.H. Gluck Equine Research Center, Veterinary Science Department, University of Kentucky, Lexington, KY, USA.
Cytogenet Genome Res. 2008;120(1-2):42-9. doi: 10.1159/000118739. Epub 2008 Apr 30.
Cytogenetic analyses of horses have benefited the horse industry by identifying chromosomal aberrations causing congenital abnormalities, embryonic loss and infertility. Technical advances in cytogenetics enabled the identification of chromosome specific aberrations. More recently, advances in genomic tools have been used to more precisely define chromosome abnormalities. In this report we review the history of equine clinical cytogenetics, identify historical landmarks for equine clinical cytogenetics, discuss how the current use of genomic tools has benefited this area, and how future genomics tools may enhance clinical cytogenetic studies in the horse.
对马的细胞遗传学分析通过识别导致先天性异常、胚胎损失和不育的染色体畸变,使养马业受益。细胞遗传学的技术进步使得能够识别特定染色体的畸变。最近,基因组工具的进展已被用于更精确地定义染色体异常。在本报告中,我们回顾了马临床细胞遗传学的历史,确定了马临床细胞遗传学的历史里程碑,讨论了基因组工具的当前应用如何使该领域受益,以及未来的基因组工具可能如何加强马的临床细胞遗传学研究。