聚（ADP-核糖）聚合酶-1：一个神秘的国际分子。

Poly ADP-ribose polymerase-1: an international molecule of mystery.

作者信息

Woodhouse Bethany C, Dianov Grigory L

机构信息

Medical Research Council Radiation Oncology & Biology Unit, University of Oxford, Oxford OX3 7DQ, UK.

出版信息

DNA Repair (Amst). 2008 Jul 1;7(7):1077-86. doi: 10.1016/j.dnarep.2008.03.009. Epub 2008 May 12.

DOI:10.1016/j.dnarep.2008.03.009

PMID:18468963

Abstract

Poly(ADP-ribose) polymerase-1 (PARP-1) is one of the most abundant proteins within mammalian cells. First described more than 45 years ago, PARP-1 has been the subject of many studies and was shown to be involved in multiple aspects of cellular metabolism. Despite many interesting studies that implicate PARP-1 in transcription, chromatin remodelling, apoptosis, DNA repair and several neurological disorders, its precise role is still unclear. This review will discuss the role of PARP-1 in DNA repair and propose a model whereby PARP-1 operates as a modulator of base excision repair capacity.

摘要

聚（ADP - 核糖）聚合酶 -1（PARP -1）是哺乳动物细胞中含量最丰富的蛋白质之一。45多年前首次被描述以来，PARP -1一直是众多研究的对象，并被证明参与细胞代谢的多个方面。尽管有许多有趣的研究表明PARP -1与转录、染色质重塑、细胞凋亡、DNA修复以及几种神经系统疾病有关，但其确切作用仍不清楚。本综述将讨论PARP -1在DNA修复中的作用，并提出一个模型，即PARP -1作为碱基切除修复能力的调节剂发挥作用。