Woodland D L, Happ M P, Gollob K J, Palmer E
Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38106.
Nature. 1991 Feb 7;349(6309):529-30. doi: 10.1038/349529a0.
A special class of self-antigens (endogenous superantigens) is capable of deleting many murine T cells on the basis of their expression of particular T-cell receptor V beta gene segments. In mice that endogenously express these antigens, tolerance is mediated in part by the clonal deletion of the relevant V beta-bearing T cells. The deletion of I-E-reactive V beta 5.2-bearing T cells is dependent on the coexpression of an I-E tolerogenic coligand (Etc)14 and the gene for one of these coligands, Etc-1, maps to chromosome 12, near the mouse mammary tumour viral integrant, Mtv-9. Here we report a perfect genetic linkage between Etc-1 and Mtv-9 and show that Etc-1 is also involved in the I-E-dependent deletion of T cells bearing V beta 5.1 and V beta 11 domains. We also demonstrate that Mtv-9 transcripts are present in B cells expressing Etc-1 and suggest that the coligand recognized by roughly 15% of all T lymphocytes is encoded by the Mtv-9 genome.
一类特殊的自身抗原（内源性超抗原）能够基于特定T细胞受体Vβ基因片段的表达而清除许多小鼠T细胞。在体内表达这些抗原的小鼠中，耐受性部分是由相关的携带Vβ的T细胞的克隆清除介导的。I-E反应性携带Vβ5.2的T细胞的清除依赖于I-E耐受性共配体（Etc）14的共表达，并且这些共配体之一的基因Etc-1定位于12号染色体上，靠近小鼠乳腺肿瘤病毒整合体Mtv-9。在此，我们报告了Etc-1与Mtv-9之间存在完美的遗传连锁，并表明Etc-1也参与了携带Vβ5.1和Vβ11结构域的T细胞的I-E依赖性清除。我们还证明，在表达Etc-1的B细胞中存在Mtv-9转录本，并表明大约15%的所有T淋巴细胞识别的共配体是由Mtv-9基因组编码的。
