铅灰毛霉对二萜类化合物穆林-11,13-二烯-20-酸的微生物转化

Microbial transformation of the diterpene mulin-11,13-dien-20-oic acid by Mucor plumbeus.

作者信息

Areche Carlos, Loyola Luis A, Borquez Jorge, Rovirosa Juana, San-Martin Aurelio

机构信息

Department of Chemistry, Faculty of Sciences, University of Chile, Santiago, Chile.

出版信息

Magn Reson Chem. 2008 Aug;46(8):765-8. doi: 10.1002/mrc.2238.

DOI:10.1002/mrc.2238

PMID:18470864

Abstract

Two new mulinane-type derivatives: 16-hydroxy mulin-11,13-dien-20-oic (2) acid and 7alpha,16-dihydroxy mulin-11,13-dien-20-oic (3) acid were obtained by microbial transformation of mulin-11,13-dien-20-oic acid (1), along with tyrosol (4) using liquid cultures of Mucor plumbeus. The latter compound has not been previously identified in the genus Mucor. Structural elucidation of these metabolites was achieved using 1D- and 2D-NMR spectroscopy.

摘要

通过毛霉（Mucor plumbeus）的液体培养，以11,13-二烯-20-乌苏酸（1）为底物，微生物转化得到了两种新的木藜芦烷型衍生物：16-羟基-11,13-二烯-20-乌苏酸（2）和7α,16-二羟基-11,13-二烯-20-乌苏酸（3），同时还得到了酪醇（4）。后一种化合物在毛霉属中尚未见报道。这些代谢产物的结构通过一维和二维核磁共振光谱得以阐明。