Haugen Brian, Werner Liliana, Romaniv Natalya, Haymore Jonathan, Kleinmann Guy, Mamalis Nick, Olson Randall J
John A. Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA.
J Cataract Refract Surg. 2008 May;34(5):853-8. doi: 10.1016/j.jcrs.2008.01.011.
To compare the prophylaxis of collagen shields presoaked in antibiotics versus antibiotic drops after bacterial anterior chamber challenge.
John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
Forty rabbits received bilateral 0.03 mL intracameral injections of Staphylococcus epidermidis (5 x 10(8) colony-forming units). Four groups of 10 rabbits had their eyes randomized to receive (1) 3 mg/mL gatifloxacin (Zymar) drops or shield in Zymar, (2) Zymar drops or shield in 10 mg/mL gatifloxacin (Tequin), (3) 5 mg/mL moxifloxacin (Vigamox) drops or shield in Vigamox, or (4) balanced salt solution (BSS) drops or shield in BSS. Each eye received Zymar, Vigamox, or BSS 4 times 1 hour before injection. The antibiotic-BSS was administered every 2 hours (5 doses total). One day later, signs of endophthalmitis were scored under the slitlamp.
Groups 1 and 2 had significantly lower endophthalmitis incidences (total score > or = 8) than the BSS controls. Shield scores were not significantly different from those of the counterpart drops. The comparison between drops was not significant (P = .0513); the difference between shields (P = .0232) and the post-comparison Zymar versus BSS shields (P = .0021) were significant.
Topical therapy with gatifloxacin before and after intraocular bacteria challenge led to lower incidences of endophthalmitis in rabbits. Prophylaxis with presoaked collagen shields was not statistically different than that with topical drops.
比较细菌前房攻击后预先浸泡抗生素的胶原盾与抗生素滴眼液的预防效果。
美国犹他州盐湖城犹他大学约翰·A·莫兰眼科中心。
40只兔子双眼前房内注射0.03 mL表皮葡萄球菌（5×10⁸菌落形成单位）。10只兔子为一组，共四组，其眼睛随机接受以下处理：（1）3 mg/mL加替沙星（适利达）滴眼液或浸泡在适利达中的胶原盾；（2）10 mg/mL加替沙星（特美汀）滴眼液或浸泡在特美汀中的胶原盾；（3）5 mg/mL莫西沙星（维莫星）滴眼液或浸泡在维莫星中的胶原盾；或（4）平衡盐溶液（BSS）滴眼液或浸泡在BSS中的胶原盾。每只眼睛在注射前1小时接受4次适利达、维莫星或BSS滴眼。抗生素 - BSS每2小时给药一次（共5剂）。一天后，在裂隙灯下对眼内炎体征进行评分。
第1组和第2组的眼内炎发生率（总分≥8）显著低于BSS对照组。胶原盾组的评分与相应滴眼液组无显著差异。滴眼液组之间的比较无显著差异（P = 0.0513）；胶原盾组之间的差异（P = 0.0232）以及比较后适利达胶原盾与BSS胶原盾之间的差异（P = 0.0021）具有统计学意义。
眼内细菌攻击前后局部应用加替沙星可降低兔子眼内炎的发生率。预先浸泡的胶原盾预防效果与局部滴眼液相比无统计学差异。
