Li Ni, Zhou Zongguang, Liu Xuyang, Liu Yi, Zhang Junjun, Du Liang, Wei Maoling, Chen Xiaoming
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
Clin Biochem. 2008 Jul;41(10-11):881-6. doi: 10.1016/j.clinbiochem.2008.04.014. Epub 2008 Apr 26.
To quantitatively summarize the association between tumour necrosis factor alpha (TNF-alpha) gene polymorphisms and Graves' disease.
Relevant studies were identified from the following electronic databases: Cochrane Library, MEDLINE, EMBASE and Chinese Bio-medicine Database. A meta-analysis of relevant studies was performed.
This meta-analysis included 10 case-control studies, which included 2271 Graves' disease cases and 2633 controls. The combined results based on all studies showed that there was significant difference in genotype distribution (-308A/G; -308G/G; -863C/C; -863C/A; -1031C/T) between Graves' disease and controls. When stratifying for race, statistically significant results were observed in three genotype distribution (-863C/C; -863C/A; -1031C/T) between Graves' disease and controls among Asians. Statistically significant results were observed in only two genotype distribution (-308A/G; -308G/G) between Graves' disease and controls among Caucasians.
This meta-analysis suggests that TNF-alpha gene polymorphisms at positions -308 (G-308A), -863 (C-863A), and -1031 (T-1031C) were associated with Graves' disease.
定量总结肿瘤坏死因子α（TNF-α）基因多态性与格雷夫斯病之间的关联。
从以下电子数据库中检索相关研究：考克兰图书馆、医学文献数据库、荷兰医学文摘数据库及中国生物医学数据库。对相关研究进行荟萃分析。
该荟萃分析纳入了10项病例对照研究，其中包括2271例格雷夫斯病患者和2633例对照。基于所有研究的合并结果显示，格雷夫斯病与对照之间在基因型分布（-308A/G；-308G/G；-863C/C；-863C/A；-1031C/T）上存在显著差异。按种族分层时，在亚洲人群中，格雷夫斯病与对照之间在三种基因型分布（-863C/C；-863C/A；-1031C/T）上观察到具有统计学意义的结果。在白种人群中，格雷夫斯病与对照之间仅在两种基因型分布（-308A/G；-308G/G）上观察到具有统计学意义的结果。
该荟萃分析表明，位于-308（G-308A）、-863（C-863A）和-1031（T-1031C）位点的TNF-α基因多态性与格雷夫斯病相关。
