不溶性糖原，一种可代谢的内源性吸附剂，可降低内毒素休克大鼠的致死率。
Insoluble glycogen, a metabolizable internal adsorbent, decreases the lethality of endotoxin shock in rats.
机构信息
3rd Department of Internal Medicine, University Medical School of Debrecen, Hungary.
出版信息
Mediators Inflamm. 1997;6(5-6):319-22. doi: 10.1080/09629359791442.
Insoluble glycogen is an enzymatically modified form of naturally occurring soluble glycogen with a great adsorbing capacity. It can be metabolized by phagocytes to glucose. In this study we used insoluble glycogen intravenously in the experimental endotoxin shock of rats. Wistar male rats were sensitized to endotoxin by Pb acetate. The survival of rats were compared in groups of animals endotoxin shock treated and non-treated with insoluble glycogen. Furthermore, we have determined in vitro the binding capacity of insoluble glycogen for endotoxin, tumour necrosis factor alpha, interleukin-1 and secretable phospholipase A2. Use of 10 mg/kg dose of insoluble glycogen could completely prevent the lethality of shock induced by LD50 quantity of endotoxin in rats. All animals treated survived. Insoluble glycogen is a form of 'metabolizable internal adsorbents'. It can potentially be used for treatment of septic shock.
不溶性糖原是一种酶法修饰的天然可溶性糖原形式，具有很强的吸附能力。它可以被吞噬细胞代谢为葡萄糖。在这项研究中，我们在大鼠实验性内毒素休克中静脉内使用不溶性糖原。Wistar 雄性大鼠用醋酸铅致敏内毒素。比较了用和未用不溶性糖原治疗内毒素休克的动物组的大鼠存活率。此外，我们还在体外测定了不溶性糖原与内毒素、肿瘤坏死因子-α、白细胞介素-1 和可分泌的磷脂酶 A2 的结合能力。使用 10mg/kg 剂量的不溶性糖原可以完全预防 LD50 剂量内毒素诱导的大鼠休克的致死性。所有接受治疗的动物都存活下来。不溶性糖原是一种“可代谢的内吸附剂”形式。它可能可用于治疗感染性休克。
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