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Chem Cent J. 2018 Sep 29;12(1):101. doi: 10.1186/s13065-018-0469-3.
2
Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes.甾体缩氨基硫脲铂（II）配合物的合成与抗增殖活性
Bioinorg Chem Appl. 2015;2015:742592. doi: 10.1155/2015/742592. Epub 2015 Oct 8.
3
DNA binding, antioxidant, cytotoxicity (MTT, lactate dehydrogenase, NO), and cellular uptake studies of structurally different nickel(II) thiosemicarbazone complexes: synthesis, spectroscopy, electrochemistry, and X-ray crystallography.结构不同的镍（II）硫代半卡巴腙配合物的 DNA 结合、抗氧化、细胞毒性（MTT、乳酸脱氢酶、NO）和细胞摄取研究：合成、光谱学、电化学和 X 射线晶体学。
J Biol Inorg Chem. 2013 Feb;18(2):233-247. doi: 10.1007/s00775-012-0969-x. Epub 2012 Dec 29.
4
Cytotoxicity in human cancer cells and mitochondrial dysfunction induced by a series of new copper(I) complexes containing tris(2-cyanoethyl)phosphines.新型含三（2-氰乙基）膦铜（I）配合物诱导人癌细胞毒性和线粒体功能障碍。
Invest New Drugs. 2011 Dec;29(6):1213-23. doi: 10.1007/s10637-010-9466-7. Epub 2010 Jun 22.

激素锚定金属配合物。1. 醋酸睾酮缩氨基硫脲及其金属配合物的合成、结构、光谱和体外抗肿瘤活性

Hormone anchored metal complexes. 1. Synthesis, structure, spectroscopy and in vitro antitumor activity of testosterone acetate thiosemicarbazone and its metal complexes.

作者信息

Murugkar A, Unnikrishnan B, Padhye S, Bhonde R, Teat S, Triantafillou E, Sinn E

机构信息

Department of Chemistry University of Pune Pune 411007 India.

出版信息

Met Based Drugs. 1999;6(3):177-82. doi: 10.1155/MBD.1999.177.

DOI:10.1155/MBD.1999.177
PMID:18472909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2366831/
Abstract

Testosterone acetate thiosemicarbazone (TATSC, 17-beta-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl(1)] followed by [Cu(TATSC)Cl(2)] and the ligand in compariosn with cisplatin.

摘要

合成了醋酸睾酮缩氨基硫脲（TATSC，17-β-羟基雄甾-4-酮醋酸缩氨基硫脲），并通过单晶X射线结构测定对其进行了表征。合成了这种甾体衍生物的铜和铂配合物，并通过光谱学和电化学对其进行了表征。测试了这些化合物对人乳腺癌细胞系MCF-7的体外活性。发现[Pt(TATSC)Cl(1)]的活性最高，其次是[Cu(TATSC)Cl(2)]，与顺铂相比，配体也有活性。