Roche Marjolaine, Rondeau Philippe, Singh Nihar Ranjan, Tarnus Evelyne, Bourdon Emmanuel
Laboratoire de Biochimie et Génétique Moléculaire, Université de La Réunion, Saint Denis de La Réunion, France.
FEBS Lett. 2008 Jun 11;582(13):1783-7. doi: 10.1016/j.febslet.2008.04.057. Epub 2008 May 12.
Free radicals are a normal component of cellular oxygen metabolism in mammals. However, free radical-associated damage is an important factor in many pathological processes. Glycation and oxidative damage cause protein modifications, frequently observed in numerous diseases. Albumin represents a very abundant and important circulating antioxidant. This review brings together recent insights on albumin antioxidant properties. First, it focuses on the different activities of albumin concerning protein antioxidation. In particular, we describe the role of albumin in ligand binding and free radical-trapping activities. In addition, physiological and pathological situations that modify the antioxidant properties of albumin are reported.
自由基是哺乳动物细胞氧代谢的正常组成部分。然而，自由基相关损伤是许多病理过程中的一个重要因素。糖基化和氧化损伤会导致蛋白质修饰，这在许多疾病中经常出现。白蛋白是一种非常丰富且重要的循环抗氧化剂。本综述汇集了关于白蛋白抗氧化特性的最新见解。首先，它关注白蛋白在蛋白质抗氧化方面的不同活性。特别是，我们描述了白蛋白在配体结合和自由基捕获活性中的作用。此外，还报道了改变白蛋白抗氧化特性的生理和病理情况。
