在慢性粒细胞白血病中观察到一种新型的五向染色体易位。
A novel five-way chromosomal translocation observed in chronic myelogenous leukemia.
作者信息
Ikuta Katsuya, Torimoto Yoshihiro, Jimbo Junko, Inamura Junki, Hosoki Takaaki, Shindo Motohiro, Sato Kazuya, Takahashi Hiroyuki, Kohgo Yutaka
机构信息
Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, 2-1-1-1, Midorigaoka-Higashi, Asahikawa, Hokkaido, Japan 078-8510.
出版信息
Cancer Genet Cytogenet. 2008 May;183(1):69-71. doi: 10.1016/j.cancergencyto.2008.02.002.
Most patients with chronic myelogenous leukemia (CML) show a Philadelphia (Ph) chromosome with a characteristic translocation between chromosomes 9 and 22. However, there are variant complex translocations involving other chromosomes in addition to the standard translocation. We describe a case of CML showing a complex and novel chromosomal translocation involving five chromosomes, t(4;12;7;9;22).
大多数慢性粒细胞白血病（CML）患者显示出费城（Ph）染色体，其特征是9号和22号染色体之间发生易位。然而，除了标准易位外，还有涉及其他染色体的变异复杂易位。我们描述了一例CML病例，其显示出涉及五条染色体的复杂且新颖的染色体易位，即t(4;12;7;9;22)。
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