• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一名慢性髓性白血病患者中涉及费城染色体的新型五重易位t(7;11;9;22;9)(q22;q13;q34;q11.2;q34):病例报告

A novel five-way translocation t(7;11;9;22;9)(q22;q13;q34;q11.2;q34) involving Ph chromosome in a patient of chronic myeloid leukemia: a case report.

作者信息

Yokota Sho, Nakamura Yuichi, Bessho Masami

机构信息

Department of Hematology, Saitama Medical University Hospital, 38 Moro-Hongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

出版信息

Mol Cytogenet. 2012 May 1;5(1):20. doi: 10.1186/1755-8166-5-20.

DOI:10.1186/1755-8166-5-20
PMID:22548843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3407734/
Abstract

About 5-10 % of chronic myelogenous leukemia (CML) patients show variant Philadelphia (Ph) translocations. The formation mechanisms and clinical significance of variant Ph translocations remain unclear. We report a CML case with a novel five-way complex translocation. Although the result of initial G-banding was 46,XY,t(7;11;9)(q22;q13;q34),t(9;22)(q34;q11.2), fluorescence in situ hybridization (FISH) demonstrated t(7;11;9;22;9)(q22;q13;q34;q11.2;q34) consisting of sequential rearrangements involving five chromosomes. The patient was successfully treated by imatinib and obtained a major molecular response. To our knowledge, this is the tenth CML case with a complicated Ph translocation involving five chromosomes and the third one treated by imatinib. Good response with imatinib therapy suggested that a single-event rearrangement was involved in the chromosomal changes.

摘要

约5%-10%的慢性粒细胞白血病(CML)患者存在变异型费城(Ph)染色体易位。变异型Ph染色体易位的形成机制及临床意义尚不清楚。我们报告1例伴有新型五重复杂易位的CML病例。尽管最初的G显带结果为46,XY,t(7;11;9)(q22;q13;q34),t(9;22)(q34;q11.2),但荧光原位杂交(FISH)显示为t(7;11;9;22;9)(q22;q13;q34;q11.2;q34),由涉及五条染色体的连续重排组成。该患者接受伊马替尼治疗成功并获得主要分子反应。据我们所知,这是第10例伴有涉及五条染色体的复杂Ph染色体易位的CML病例,也是第3例接受伊马替尼治疗的此类病例。伊马替尼治疗反应良好提示染色体改变涉及单一事件重排。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/3407734/e2acaaf1a438/1755-8166-5-20-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/3407734/8e84f2df1ba9/1755-8166-5-20-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/3407734/ab1898846e67/1755-8166-5-20-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/3407734/e2acaaf1a438/1755-8166-5-20-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/3407734/8e84f2df1ba9/1755-8166-5-20-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/3407734/ab1898846e67/1755-8166-5-20-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08a2/3407734/e2acaaf1a438/1755-8166-5-20-3.jpg

相似文献

1
A novel five-way translocation t(7;11;9;22;9)(q22;q13;q34;q11.2;q34) involving Ph chromosome in a patient of chronic myeloid leukemia: a case report.一名慢性髓性白血病患者中涉及费城染色体的新型五重易位t(7;11;9;22;9)(q22;q13;q34;q11.2;q34):病例报告
Mol Cytogenet. 2012 May 1;5(1):20. doi: 10.1186/1755-8166-5-20.
2
Variant Philadelphia translocations with different breakpoints in six chronic myeloid leukemia patients.6例慢性髓性白血病患者中具有不同断点的变异型费城染色体易位
Turk J Haematol. 2011 Sep 5;28(3):186-92. doi: 10.5152/tjh.2011.52.
3
Three-way Philadelphia translocation t(9;10;22)(q34;p11.2;q11.2) as a secondary abnormality in an imatinib mesylate-resistant chronic myeloid leukemia patient.三向费城易位t(9;10;22)(q34;p11.2;q11.2)作为甲磺酸伊马替尼耐药慢性髓性白血病患者的继发异常。
Oncol Lett. 2013 May;5(5):1656-1658. doi: 10.3892/ol.2013.1228. Epub 2013 Mar 5.
4
A Novel Four-Way Complex Variant Translocation Involving Chromosome 46,XY,t(4;9;19;22)(q25:q34;p13.3;q11.2) in a Chronic Myeloid Leukemia Patient.一名慢性髓性白血病患者中涉及染色体46,XY,t(4;9;19;22)(q25:q34;p13.3;q11.2)的新型四向复杂变异易位
Front Oncol. 2016 May 30;6:124. doi: 10.3389/fonc.2016.00124. eCollection 2016.
5
A novel cytogenetic abnormality t(7;8)(p11.2:q11.2) and a four-way Philadelphia translocation in an imatinib mesylate-resistant chronic myeloid leukemia patient.一名甲磺酸伊马替尼耐药的慢性髓性白血病患者中出现一种新的细胞遗传学异常t(7;8)(p11.2:q11.2)和一种复杂的费城染色体易位。
Oncol Lett. 2013 Feb;5(2):617-620. doi: 10.3892/ol.2012.1037. Epub 2012 Nov 21.
6
A chronic myeloid leukemia case with a unique variant Philadelphia translocation: t(9;22;21)(q34;q11;p12).一例具有独特变异型费城染色体易位:t(9;22;21)(q34;q11;p12)的慢性髓性白血病病例。
Oncol Lett. 2012 May;3(5):1027-1029. doi: 10.3892/ol.2012.623. Epub 2012 Feb 28.
7
Co-existence of isodicentric Ph chromosomes and the three-way Ph chromosome variant t(3;9;22)(p21;q34;q11) in a rare case of chronic myeloid leukemia.罕见慢性髓系白血病病例中,等臂双中心Ph染色体与三体Ph染色体变异t(3;9;22)(p21;q34;q11)共存。
Oncol Lett. 2018 Apr;15(4):4599-4603. doi: 10.3892/ol.2018.7866. Epub 2018 Jan 26.
8
Cytogenetical and hematological analysis of chronic myelogenous leukemia patients with a novel case 52XX, t (1;9;22) (q23.3; q34; q11.2), +6, +8, i(9) (q10;q10), +18,+19,+21+der22 t(9;22)(q34;q11).慢性髓性白血病患者的细胞遗传学和血液学分析,伴有一个新的病例 52XX,t (1;9;22) (q23.3; q34; q11.2),+6,+8,i(9) (q10;q10),+18,+19,+21+der22 t(9;22) (q34;q11)。
Medicine (Baltimore). 2022 Nov 11;101(45):e31670. doi: 10.1097/MD.0000000000031670.
9
Molecular cytogenetic characterization of Philadelphia-negative rearrangements in chronic myeloid leukemia patients.慢性髓性白血病患者费城阴性重排的分子细胞遗传学特征。
J Cancer Res Clin Oncol. 2011 Sep;137(9):1329-36. doi: 10.1007/s00432-011-1002-4. Epub 2011 Jul 8.
10
Variant Ph translocations in chronic myeloid leukemia.慢性髓性白血病中的变异Ph易位
Cancer Genet Cytogenet. 1985 Nov;18(3):215-27. doi: 10.1016/0165-4608(85)90086-x.

引用本文的文献

1
The first case of six-way complex translocation of t(4;7;9;22;8;14) in a patient with chronic myeloid leukemia.首例慢性髓性白血病患者的 t(4;7;9;22;8;14)六向复杂易位。
J Hematop. 2024 Jun;17(2):97-101. doi: 10.1007/s12308-024-00577-8. Epub 2024 Mar 16.
2
The spectrum of chromosomal translocations in the Arab world: ethnic-specific chromosomal translocations and their relevance to diseases.阿拉伯世界的染色体易位谱:特定于种族的染色体易位及其与疾病的相关性。
Chromosoma. 2022 Sep;131(3):127-146. doi: 10.1007/s00412-022-00775-2. Epub 2022 Jul 30.
3
Saudi Arabian CML patient with a novel four-way translocation at t(9;22;5;2)(q34;q11.2;p13;q44).

本文引用的文献

1
Influence of complex variant chromosomal translocations in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.酪氨酸激酶抑制剂治疗慢性髓性白血病患者中复杂变异染色体易位的影响。
Acta Oncol. 2010 May;49(4):506-8. doi: 10.3109/02841861003660031.
2
Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report.费城染色体阳性慢性髓系白血病中涉及5条不同染色体的新型复杂易位:1例报告
Mol Cytogenet. 2009 Nov 9;2:21. doi: 10.1186/1755-8166-2-21.
3
European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor.
沙特阿拉伯一位 CML 患者出现新型四向易位 t(9;22;5;2)(q34;q11.2;p13;q44)。
Mol Genet Genomic Med. 2022 Jun;10(6):e1865. doi: 10.1002/mgg3.1865. Epub 2022 May 11.
4
Molecular, Cytogenetic, and Hematological Analysis of Chronic Myeloid Leukemia Patients and Discovery of Two Novel Translocations.慢性髓性白血病患者的分子、细胞遗传学和血液学分析以及两种新型易位的发现
Anal Cell Pathol (Amst). 2021 Aug 12;2021:4909012. doi: 10.1155/2021/4909012. eCollection 2021.
5
A novel t(9;22;11) translocation involving 11q24 in a patient with chronic myeloid leukemia: A case report.一名慢性髓性白血病患者中涉及11q24的新型t(9;22;11)易位:病例报告
Oncol Lett. 2017 Mar;13(3):1711-1713. doi: 10.3892/ol.2017.5668. Epub 2017 Feb 1.
欧洲白血病网关于治疗失败或反应欠佳的标准能够可靠地识别出伊马替尼治疗的慢性期早期慢性粒细胞白血病患者,这些患者最终预后较差。
Blood. 2008 Dec 1;112(12):4437-44. doi: 10.1182/blood-2008-06-162388. Epub 2008 Aug 20.
4
A novel five-way chromosomal translocation observed in chronic myelogenous leukemia.在慢性粒细胞白血病中观察到一种新型的五向染色体易位。
Cancer Genet Cytogenet. 2008 May;183(1):69-71. doi: 10.1016/j.cancergencyto.2008.02.002.
5
Results of imatinib mesylate therapy in chronic myelogenous leukaemia with variant Philadelphia chromosome.甲磺酸伊马替尼治疗伴有变异型费城染色体的慢性粒细胞白血病的结果
Br J Haematol. 2004 Apr;125(2):187-95. doi: 10.1111/j.1365-2141.2004.04899.x.
6
Contribution of fluorescence in situ hybridization analyses to the characterization of masked and complex Philadelphia chromosome translocations in chronic myelocytic leukemia.荧光原位杂交分析对慢性粒细胞白血病中隐匿性和复杂费城染色体易位特征描述的贡献。
Cancer Genet Cytogenet. 2003 Dec;147(2):115-20. doi: 10.1016/s0165-4608(03)00204-8.
7
Survival implications of molecular heterogeneity in variant Philadelphia-positive chronic myeloid leukaemia.变异型费城染色体阳性慢性髓性白血病分子异质性的生存意义
Br J Haematol. 2003 May;121(3):419-27. doi: 10.1046/j.1365-2141.2003.04291.x.
8
Highly complex chromosomal rearrangement of chromosome 9 in a case of chronic myeloid leukemia.一例慢性髓系白血病患者中9号染色体的高度复杂染色体重排
Cancer Genet Cytogenet. 1998 Jul 15;104(2):153-6. doi: 10.1016/s0165-4608(97)00451-2.
9
A Philadelphia chromosome positive CML patient with a unique translocation studied via GTG-banding and fluorescence in situ hybridization.一名费城染色体阳性的慢性粒细胞白血病患者,通过GTG显带和荧光原位杂交技术对其独特的易位进行了研究。
Cancer Genet Cytogenet. 1996 Jul 15;89(2):157-62. doi: 10.1016/0165-4608(96)00029-5.
10
Philadelphia-negative chronic myeloid leukaemia: detection by FISH of BCR-ABL fusion gene localized either to chromosome 9 or chromosome 22.
Br J Haematol. 1994 Jun;87(2):409-12. doi: 10.1111/j.1365-2141.1994.tb04933.x.