Martin-Moutot Nicole, De Haro Luc, Seagar Michael
INSERM, U641, Marseille F-13000, France.
J Neuroimmunol. 2008 Jun 15;197(1):47-53. doi: 10.1016/j.jneuroim.2008.04.001. Epub 2008 May 13.
To determine whether titers of anti-P/Q type and anti-N type calcium channel antibodies provide distinct information, both types of assay were performed during follow-up of 7 patients with Lambert-Eaton myasthenic syndrome (LEMS). In 4 patients with both antibody responses, titers evolved independently and often in an inverse relationship. Two patients with squamous cell lung carcinoma (SqCLC) produced anti-N type channel antibodies, but no detectable anti-P/Q channel responses. These results suggest that anti-N channel autoantibodies constitute an immune response distinct from the anti-P/Q type channel specificity and can also correlate with clinical evolution. Consequently combined assays may provide more comprehensive information during follow-up of LEMS.
为了确定抗P/Q型和抗N型钙通道抗体的滴度是否能提供不同的信息，在对7例兰伯特-伊顿肌无力综合征（LEMS）患者的随访过程中进行了这两种检测。在4例产生两种抗体反应的患者中，抗体滴度独立变化，且常常呈负相关。2例鳞状细胞肺癌（SqCLC）患者产生了抗N型通道抗体，但未检测到抗P/Q通道反应。这些结果表明，抗N通道自身抗体构成了一种不同于抗P/Q型通道特异性的免疫反应，并且也可能与临床进展相关。因此，联合检测可能在LEMS的随访过程中提供更全面的信息。
