James E C, Schuchmann G F, Hall R V, Patterson J R, Gillespie J T, Gomez A C
Ann Thorac Surg. 1976 Aug;22(2):157-62. doi: 10.1016/s0003-4975(10)63978-1.
An analysis of our experience with 48 patients having bronchiolar or alveolar cell carcinoma is reported. The remarkable biological variability of this peripheral tumor has important surgical implications. Basically, two dominant clinical presentations occur. In the less common diffuse or multinodular form, prolonged survival is infrequent regardless of the therapeutic approach. Often these patients die from respiratory compromise due to the tumor itself. In the more common localized or solitary form the prognosis for cure is good, approximating 47% or higher. Based on the material presented, lobectomy is the preferred method of surgical treatment. In patients manifesting multinodular disease, surgical resection rarely seems warranted. The concept of preserving pulmonary tissue is stressed.
本文报道了对48例细支气管肺泡癌患者的经验分析。这种周围型肿瘤显著的生物学变异性具有重要的手术意义。基本上，有两种主要的临床表现形式。在较不常见的弥漫性或多结节性形式中，无论采用何种治疗方法，长期生存都不常见。这些患者常常死于肿瘤本身导致的呼吸功能不全。在较常见的局限性或孤立性形式中，治愈的预后良好，治愈率接近47%或更高。根据所提供的资料，肺叶切除术是首选的手术治疗方法。对于表现为多结节性病变的患者，很少有手术切除的必要。强调了保留肺组织的概念。
