Peters P J, Neefjes J J, Oorschot V, Ploegh H L, Geuze H J
Laboratory of Cell Biology, Medical School, University of Utrecht, The Netherlands.
Nature. 1991 Feb 21;349(6311):669-76. doi: 10.1038/349669a0.
Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively. In human B lymphoblastoid cells, class I molecules are present in compartments constituting the biosynthetic pathway, whereas class II molecules enter structures related to lysosomes during their biosynthesis.
MHC分子的转运决定了呈递给T细胞的肽段来源。MHC I类和II类分子的细胞内分布分别反映了内源性和外源性抗原呈递的二分法。在人B淋巴母细胞中，I类分子存在于构成生物合成途径的区室中，而II类分子在其生物合成过程中进入与溶酶体相关的结构。
