Department of Pharmacology Faculty of Pharmacy Anadolu University Eskieşhir 26470 Turkey.
Mediators Inflamm. 1993;2(4):309-15. doi: 10.1155/S0962935193000432.
The effects of trifluoperazine and verapamil on bradykinin- and des-Arg(9)-bradykinin induced responses of isolated rat duodenum and guinea-pig ileum were investigated to elucidate post-bradykinin receptor events. Verapamil and trifluoperazine inhibited bradykinin induced relaxations and contractions and des-Arg(9)- bradykinin induced contractions in rat duodenum. Bradykinin induced contractions of ileum were also inhibited by trifluoperazine and. verapamil. Since non-competitive affinity constants of trifluoperazine and verapamil for the relaxant responses to bradykinin in duodenum and for the contractile responses to bradykinin in ileum are different, post-bradykinin receptor events related to calcium may be different in ileum and duodenum. In addition, affinity constants of bradykinin in guinea-pig ileum and rat duodenum are also disparate suggesting the presence of different types of bradykinin B(2) receptors in these two organs.
研究了三氟拉嗪和异搏定对分离的大鼠十二指肠和豚鼠回肠中缓激肽和去精氨酸(9)-缓激肽诱导反应的影响,以阐明缓激肽受体后的事件。异搏定和三氟拉嗪抑制大鼠十二指肠中缓激肽诱导的松弛和收缩以及去精氨酸(9)-缓激肽诱导的收缩。三氟拉嗪和异搏定也抑制了缓激肽诱导的回肠收缩。由于三氟拉嗪和异搏定对十二指肠中缓激肽引起的松弛反应和回肠中缓激肽引起的收缩反应的非竞争性亲和力常数不同,回肠和十二指肠中与钙有关的缓激肽受体后事件可能不同。此外,豚鼠回肠和大鼠十二指肠中缓激肽的亲和力常数也存在差异,这表明这两个器官中存在不同类型的缓激肽 B(2)受体。