Department of Immunology Erasmus University PO Box 1738 Rotterdam 3000 DR The Netherlands.
Mediators Inflamm. 1994;3(6):403-10. doi: 10.1155/S0962935194000566.
Allograft rejection is a complex process, which requires interactions between different cell types and a variety of soluble factors, such as cytokines. In this review we discuss the role of cytokines in the induction and effector phases of the rejection process and in the induction and maintenance of allospecific graft tolerance. Furthermore, we discuss the feasibility of clinical graft function monitoring by measuring cytokines and the possibilities for intervention in the cytokine network in order to inhibit graft rejection and eventually obtain graft acceptance.
同种异体移植排斥是一个复杂的过程，需要不同细胞类型和多种可溶性因子（如细胞因子）之间的相互作用。在这篇综述中，我们讨论了细胞因子在排斥过程的诱导和效应阶段以及诱导和维持同种异体移植物耐受中的作用。此外，我们还讨论了通过测量细胞因子来监测临床移植物功能的可行性，以及干预细胞因子网络以抑制移植物排斥并最终获得移植物接受的可能性。
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