Department of Infectious Diseases Hsiangya Hospital Hunan Medical University Hunan Changsha China.
Mediators Inflamm. 1995;4(4):289-92. doi: 10.1155/S0962935195000469.
Hellcobacter pylori is the most common cause of gastroduodenal inflammation. However, the exact immune pathogenesis is not fully understood. To look for evidence of the immunological mechanism in H. pylori associated disease, we measured cytokine interleukin-2 (IL-2) and IL-4 levels produced by peripheral blood lymphocytes (PBL) and gastric biopsies in 20 subjects with or without H. pylori infection. H. pylori can stimulate IL-2 and IL-4 production from PBL in H. pylori negative as well as H. pylori positive individuals. The spontaneous IL-2 production by PBL and gastric biopsies was greater (p < 0.0025, <0.001)in H. pylori negative individuals than that in H. pylori infected patients. Increased IL-4 levels from PBL in H. pylori infected patients were found in the presence of H. pylori (p < 0.0025). An increased spontaneous production of IL-4 from gastric biopsies was also observed in H. pylori infected patients (p < 0.025). In conclusion, an enhanced type 2 cytokine production was observed in H. pylori infected patients, which may be responsible for H. pylori chronic infection.
幽门螺杆菌是引起胃十二指肠炎症的最常见原因。然而,其确切的免疫发病机制尚未完全阐明。为了寻找与幽门螺杆菌相关疾病的免疫学机制证据,我们检测了 20 例幽门螺杆菌感染或未感染者外周血淋巴细胞(PBL)和胃活检组织中细胞因子白细胞介素-2(IL-2)和 IL-4 的水平。幽门螺杆菌可刺激 PBL 产生 IL-2 和 IL-4,无论 PBL 是否存在幽门螺杆菌感染。幽门螺杆菌阴性个体的 PBL 和胃活检组织中 IL-2 的自发产生量大于(p < 0.0025,<0.001)幽门螺杆菌感染患者。在存在幽门螺杆菌的情况下,发现幽门螺杆菌感染患者的 PBL 中 IL-4 水平升高(p < 0.0025)。还观察到幽门螺杆菌感染患者的胃活检组织中 IL-4 的自发产生量增加(p < 0.025)。总之,在幽门螺杆菌感染患者中观察到 2 型细胞因子的产生增强,这可能是幽门螺杆菌慢性感染的原因。