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2
Self-renewal of pulmonary alveolar macrophages: evidence from radiation chimera studies.
J Leukoc Biol. 1987 Nov;42(5):443-6.
3
Pathogenesis of silicosis: current concepts and hypotheses.矽肺的发病机制：当前概念与假说
Lung. 1986;164(3):139-54. doi: 10.1007/BF02713638.
4
Stimulation of arachidonic acid metabolism by adherence of alveolar macrophages to a plastic substrate. Modulation by fetal bovine serum.肺泡巨噬细胞黏附于塑料基质对花生四烯酸代谢的刺激作用。胎牛血清的调节作用。
Am Rev Respir Dis. 1988 Jan;137(1):38-43. doi: 10.1164/ajrccm/137.1.38.
5
Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action.转化生长因子β是白细胞介素1（IL-1）受体表达的强效抑制剂：对IL-1作用抑制机制的推测
J Exp Med. 1990 Sep 1;172(3):737-44. doi: 10.1084/jem.172.3.737.
6
Transforming growth factor-beta 1 inhibits lipoxygenase and epoxygenase eicosanoid production by osteosarcoma cells.转化生长因子-β1抑制骨肉瘤细胞中脂氧合酶和环氧合酶类花生四烯酸产物的生成。
Biochem Soc Trans. 1990 Dec;18(6):1259-60. doi: 10.1042/bst0181259a.
7
Transforming growth factor-beta regulation of IL-6 production by unstimulated and IL-1-stimulated human fibroblasts.转化生长因子-β对未刺激及白细胞介素-1刺激的人成纤维细胞产生白细胞介素-6的调控
J Immunol. 1991 May 15;146(10):3437-43.
8
Transforming growth factor-beta modulates eicosanoid metabolism in osteogenic osteosarcoma cells.转化生长因子-β调节成骨性骨肉瘤细胞中的类花生酸代谢。
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TGF-β(1) 对体外染矽大鼠肺泡巨噬细胞 TXB(2)和 PGE(2)生成的调节。

Regulation of TXB(2) and PGE(2) production by TGF-beta(1) in in vitro silica dust-exposed rat alveolar macrophage.

机构信息

Department of Pathology Hershey Medical Center The Pennsylvania State University P.O. Box 850 Hershey PA 17033 USA.

出版信息

Mediators Inflamm. 1995;4(6):413-6. doi: 10.1155/S0962935195000664.

DOI:10.1155/S0962935195000664
PMID:18475673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2365670/
Abstract

We investigated the effect of transforming factor factor-beta(1) (TGF-beta(1)) on thromboxane B(2) (TXB(2)) and prostaglandin E(2) (PGE(2)) production in in vitro silica dust-exposed rat alveolar macrophages (AM). In the presence of 5 mug of anti-TGF-beta(1) antibodies, TXB(2) production decreased, but PGE(2) production increased. Addition of 2 ng of TGF-beta(1) to the culture medium potentiated TXB(2) production, but PGE(2) production apparently did not change. At 50 ng of TGF-beta(1), TXB(2) production decreased, and PGE(2) production varied. Our data suggest that in rat AM: (1) both endogenous and exogenous TGF-beta(1) regulate TXB(2) production; and (2) in the absence of endogenous TGF-beta(1) the liberation of PGE(2) increases; however, exogenous TGF-beta(1) does not have a regulatory effect on PGE(2).

摘要

我们研究了转化生长因子-β1（TGF-β1）对体外二氧化硅粉尘暴露的大鼠肺泡巨噬细胞（AM）中血栓素 B2（TXB2）和前列腺素 E2（PGE2）产生的影响。在存在 5 微克抗 TGF-β1 抗体的情况下，TXB2 的产生减少，但 PGE2 的产生增加。向培养基中添加 2 纳克 TGF-β1 可增强 TXB2 的产生，但 PGE2 的产生显然没有变化。在 50 纳克 TGF-β1 时，TXB2 的产生减少，PGE2 的产生也发生变化。我们的数据表明，在大鼠 AM 中：（1）内源性和外源性 TGF-β1 均可调节 TXB2 的产生；（2）在没有内源性 TGF-β1 的情况下，PGE2 的释放增加；然而，外源性 TGF-β1 对 PGE2 没有调节作用。