Wang Yan, Huang Jiu-Yi, Cao Yi-Feng, Guo Ji-Ping, Yang Yong-Ju, Yu Xue-Hai, Shen Feng-Ying, Wang Gui-Qing
Shanghai Institute of Cerebrovascular Disease Prevention and Cure, Shanghai 201318, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2007 Dec;28(12):1171-4.
To explore the exposed level of stroke risk factors in Fengxian county of Shanghai and the relationships between risk factors and stroke.
Community based populations including 10,565 individuals aged 40 years old and over were cluster sampled from Fengxian county in 2003 or 2004. Status of exposure on common risk factors such as hypertension, cardiovascular disease, diabetes, family history of stroke, cigarette smoking, alcohol intake were gathered while cerebral vascular hemodynamic index (CVHI) was examined, with CVHI score below 75 points as abnormal. During 2003 to 2006, 78 stroke cases occurred. The relationships between risk factors and stroke were analyzed by univariate and Cox proportional hazards regression models.
Rates of exposure regarding hypertension, cardiovascular disease, diabetes, family history of stroke, obesity (BMI > or = 28 kg/m2), smoking, drinking and CVHI score abnormal were 21.14%, 6.72%, 1.88%, 5.63%, 4.17%, 34.96%, 17.81% and 29.43%, respectively. Data from Univariate analysis indicated that relative risk (95% CI) of above-mentioned risk factors were 2.76 (1.76-4.32), 2.19 (1.16-4.14), 1.52 (0.38-6.19), 1.58 (0.69-3.62), 1.24 (0.45-3.38), 1.75 (1.12-2.73), 2.10 (1.30-3.39) and 12.72 (7.02-23.06), respectively. Results from Cox proportional hazards regression models analysis showed that cigarette smoking, CVHI score abnormal were screened into equation.
Among all the risk factors, rate of hypertension was the highest while hypertension, cardiovascular disease, cigarette smoking, alcohol intake and abnomal CVHI score had remarkable etiological correlations to stroke. Abnormal CVHI score, cigarette smoking seemed to be the independent forecasting factors related to stroke.
探讨上海市奉贤区脑卒中危险因素暴露水平及其与脑卒中的关系。
2003年或2004年从奉贤区整群抽样选取10565名40岁及以上社区人群。收集高血压、心血管疾病、糖尿病、脑卒中家族史、吸烟、饮酒等常见危险因素的暴露情况，同时检测脑血管血液动力学指标（CVHI），以CVHI评分低于75分为异常。2003年至2006年期间，发生78例脑卒中病例。采用单因素和Cox比例风险回归模型分析危险因素与脑卒中的关系。
高血压、心血管疾病、糖尿病、脑卒中家族史、肥胖（BMI≥28kg/m²）、吸烟、饮酒及CVHI评分异常的暴露率分别为21.14%、6.72%、1.88%、5.63%、4.17%、34.96%、17.81%和29.43%。单因素分析数据显示，上述危险因素的相对危险度（95%CI）分别为2.76（1.76 - 4.32）、2.19（1.16 - 4.14）、1.52（0.38 - 6.19）、1.58（0.69 - 3.62）、1.24（0.45 - 3.38）、1.75（1.12 - 2.73）、2.10（1.30 - 3.39）和12.72（7.02 - 23.06）。Cox比例风险回归模型分析结果显示，吸烟、CVHI评分异常被纳入方程。
在所有危险因素中，高血压暴露率最高，高血压、心血管疾病、吸烟、饮酒及CVHI评分异常与脑卒中存在显著病因学关联。CVHI评分异常、吸烟似乎是与脑卒中相关的独立预测因素。
