Barratt R, Frost G, O'Boyle A, Millward J, Truby H
Faculty of Health Science, University of Surrey, Guildford, UK.
J Hum Nutr Diet. 2008 Jun;21(3):248-55. doi: 10.1111/j.1365-277X.2008.00870.x.
This study investigated differences in weight loss outcomes in obese women with Type 2 diabetes (T2D) compared to those without T2D attending a 6-month dietetic led 'Lifestyle' intervention. In those who had failed to reach weight loss goals using the 'Lifestyle' approach, the study further examined the effect on weight loss with the addition of sibutramine (Reductil, Abbott Laboratories, USA) over a 6-month period.
The study comprised a case-control analysis of data from 38 obese female patients (18 with T2D) from the 'Lifestyle' and 'Pharmacotherapy' clinics attending a tertiary hospital in the UK.
In the 'Lifestyle' treatment groups, those with T2D lost significantly less body weight than those without T2D [5.26 kg (4.54%) versus 9.89 kg (9.55%), respectively]. For subjects who had failed to lose weight via the 'Lifestyle' intervention, the addition of sibutramine resulted in a similar weight loss compared to their pair-matched 'Lifestyle' only 'successful' counterparts (9.66% versus 9.55%).
Not all obese women, and those with T2D in particular, will derive benefit from 'Lifestyle' advice and those who are resistant to this treatment approach may be assisted by pharmacotherapy. Dietitians can play a role in identifying those individuals who may benefit from the use of pharmacotherapy.
本研究调查了2型糖尿病（T2D）肥胖女性与未患T2D的肥胖女性在参加为期6个月的由营养师主导的“生活方式”干预后的体重减轻结果差异。对于那些采用“生活方式”方法未能达到减肥目标的人，该研究进一步考察了在6个月期间添加西布曲明（诺美亭，美国雅培实验室）对体重减轻的影响。
该研究对英国一家三级医院“生活方式”和“药物治疗”诊所的38名肥胖女性患者（18名患有T2D）的数据进行了病例对照分析。
在“生活方式”治疗组中，患有T2D的患者体重减轻明显少于未患T2D的患者[分别为5.26千克（4.54%）和9.89千克（9.55%）]。对于那些通过“生活方式”干预未能减肥的受试者，添加西布曲明后的体重减轻与配对的仅采用“生活方式”且“成功”的对照组相似（9.66%对9.55%）。
并非所有肥胖女性，尤其是患有T2D的女性，都能从“生活方式”建议中获益，而那些对这种治疗方法有抗性的人可能会从药物治疗中得到帮助。营养师可以在识别那些可能从药物治疗中获益的个体方面发挥作用。
